Identifying autism biomarkers in default mode network using sparse representation of resting-state fMRI data

Yudan Ren, Xintao Hu, Jinglei Lv, Lei Quo, Junwei Han, Tianming Liu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

5 Scopus citations

Abstract

Exploring abnormal functional connectivities in neurodevelopmental disorders have received great attention in recent years. However, identifying functionally homogeneous brain regions as nodes in functional brain connectivity analysis is still challenging. In this paper, we adopt an effective data-driven framework of sparse representation to identify brain network nodes inspired by the nature of sparse population coding of the human brain. Using the default mode network (DMN) in patients with Autism as a test-bed, we evaluate sparse coding method and compared it with widely used group-wise independent components analysis (group-ICA). The experimental results demonstrate that the network nodes identified by sparse representation are more functionally homogeneous, which may explain the superiority of sparse representation in differentiating Autism and healthy controls by brain connectivity biomarkers.

Original languageEnglish
Title of host publication2016 IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI 2016 - Proceedings
PublisherIEEE Computer Society
Pages1278-1281
Number of pages4
ISBN (Electronic)9781479923502
DOIs
StatePublished - 15 Jun 2016
Event2016 IEEE 13th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2016 - Prague, Czech Republic
Duration: 13 Apr 201616 Apr 2016

Publication series

NameProceedings - International Symposium on Biomedical Imaging
Volume2016-June
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Conference

Conference2016 IEEE 13th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2016
Country/TerritoryCzech Republic
CityPrague
Period13/04/1616/04/16

Keywords

  • autism
  • default mode network
  • functional connectivity
  • resting-state fMRI
  • sparse coding

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