Fiber-centered analysis of brain connectivities using DTI and resting state FMRI data

Jinglei Lv, Lei Guo, Xintao Hu, Tuo Zhang, Kaiming Li, Degang Zhang, Jianfei Yang, Tianming Liu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

14 Scopus citations

Abstract

Recently, inference of functional connectivity between brain regions using resting state fMRI (rsfMRI) data has attracted significant interests in the neuroscience community. This paper proposes a novel fiber-centered approach to study the functional connectivity between brain regions using high spatial resolution diffusion tensor imaging (DTI) and rsfMRI data. We measure the functional coherence of a fiber as the time series' correlation of two gray matter voxels that this fiber connects. The functional connectivity strength between two brain regions is defined as the average functional coherence of fibers connecting them. Our results demonstrate that: 1) The functional coherence of fibers is correlated with the brain regions they connect; 2) The functional connectivity between brain regions is correlated with structural connectivity. And these two patterns are consistent across subjects. These results may provide new insights into the brain's structural and functional architecture.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention, MICCAI2010 - 13th International Conference, Proceedings
Pages143-150
Number of pages8
EditionPART 2
DOIs
StatePublished - 2010
Event13th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2010 - Beijing, China
Duration: 20 Sep 201024 Sep 2010

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 2
Volume6362 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference13th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2010
Country/TerritoryChina
CityBeijing
Period20/09/1024/09/10

Keywords

  • DTI
  • functional coherence
  • functional network
  • rsfMRI
  • structural network

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