CDK12: A potent target and biomarker for human cancer therapy

Shujing Liang, Lifang Hu, Zixiang Wu, Zhihao Chen, Shuyu Liu, Xia Xu, Airong Qian

科研成果: 期刊稿件文献综述同行评审

45 引用 (Scopus)

摘要

Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcription, RNA splicing, translation, DNA damage response (DDR), cell cycle progression and cell proliferation. Recently, increasing evidence demonstrates the important role of CDK12 in various human cancers, illustrating it as both a biomarker of cancer and a potential target for cancer therapy. Here, we summarize the current knowledge of CDK12, and review the research advances of CDK12 s biological functions, especially its role in human cancers and as a potential target and biomarker for cancer therapy.

源语言英语
文章编号1483
页(从-至)1-15
页数15
期刊Cells
9
6
DOI
出版状态已出版 - 6月 2020

指纹

探究 'CDK12: A potent target and biomarker for human cancer therapy' 的科研主题。它们共同构成独一无二的指纹。

引用此