CDK12: A potent target and biomarker for human cancer therapy

Shujing Liang, Lifang Hu, Zixiang Wu, Zhihao Chen, Shuyu Liu, Xia Xu, Airong Qian

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations

Abstract

Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcription, RNA splicing, translation, DNA damage response (DDR), cell cycle progression and cell proliferation. Recently, increasing evidence demonstrates the important role of CDK12 in various human cancers, illustrating it as both a biomarker of cancer and a potential target for cancer therapy. Here, we summarize the current knowledge of CDK12, and review the research advances of CDK12 s biological functions, especially its role in human cancers and as a potential target and biomarker for cancer therapy.

Original languageEnglish
Article number1483
Pages (from-to)1-15
Number of pages15
JournalCells
Volume9
Issue number6
DOIs
StatePublished - Jun 2020

Keywords

  • Cancer therapy
  • Cell cycle
  • Cell proliferation
  • Cyclin-dependent kinase 12
  • DNA damage response
  • Gene transcription

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