Predicting cognitive declines using longitudinally enriched representations for imaging biomarkers

Alzheimer’s Disease Neuroimaging Initiative

Research output: Contribution to journalConference articlepeer-review

7 Scopus citations

Abstract

With rapid progress in high-throughput genotyping and neuroimaging, researches of complex brain disorders, such as Alzheimer’s Disease (AD), have gained significant attention in recent years. Many prediction models have been studied to relate neuroimaging measures to cognitive status over the progressions when these disease develops. Missing data is one of the biggest challenge in accurate cognitive score prediction of subjects in longitudinal neuroimaging studies. To tackle this problem, in this paper we propose a novel formulation to learn an enriched representation for imaging biomarkers that can simultaneously capture both the information conveyed by baseline neuroimaging records and that by progressive variations of varied counts of available follow-up records over time. While the numbers of the brain scans of the participants vary, the learned biomarker representation for every participant is a fixed-length vector, which enable us to use traditional learning models to study AD developments. Our new objective is formulated to maximize the ratio of the summations of a number of ℓ1-norm distances for improved robustness, which, though, is difficult to efficiently solve in general. Thus we derive a new efficient iterative solution algorithm and rigorously prove its convergence. We have performed extensive experiments on the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset. A performance gain has been achieved to predict four different cognitive scores, when we compare the original baseline representations against the learned representations with enrichments. These promising empirical results have demonstrated improved performances of our new method that validate its effectiveness.

Original languageEnglish
Article number9156727
Pages (from-to)4826-4835
Number of pages10
JournalProceedings of the IEEE Computer Society Conference on Computer Vision and Pattern Recognition
DOIs
StatePublished - 2020
Event2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition, CVPR 2020 - Virtual, Online, United States
Duration: 14 Jun 202019 Jun 2020

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