Access to Enantioenriched Organosilanes from Enals and β-Silyl Enones: Carbene Organocatalysis

Yuxia Zhang; Jie Huang; Yingying Guo; Lin Li; Zhenqian Fu; Wei Huang

doi:10.1002/anie.201800483

Access to Enantioenriched Organosilanes from Enals and β-Silyl Enones: Carbene Organocatalysis

Yuxia Zhang, Jie Huang, Yingying Guo, Lin Li, Zhenqian Fu, Wei Huang

Institute of Flexible Electronics

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Herein, an efficient route to enantioenriched organosilanes, containing two consecutive stereogenic centers, from enals and β-silyl enones under carbene organocatalysis is described. Under mild reaction conditions, this transition-metal-free strategy exhibits a broad substrate scope, and excellent diastereo- and enantioselectivity.

Original language	English
Pages (from-to)	4594-4598
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	57
Issue number	17
DOIs	https://doi.org/10.1002/anie.201800483
State	Published - 16 Apr 2018

Keywords

cyclizations
lactones
N-heterocyclic carbenes
organocatalysis
silanes

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10.1002/anie.201800483

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abstract = "Herein, an efficient route to enantioenriched organosilanes, containing two consecutive stereogenic centers, from enals and β-silyl enones under carbene organocatalysis is described. Under mild reaction conditions, this transition-metal-free strategy exhibits a broad substrate scope, and excellent diastereo- and enantioselectivity.",

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author = "Yuxia Zhang and Jie Huang and Yingying Guo and Lin Li and Zhenqian Fu and Wei Huang",

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T1 - Access to Enantioenriched Organosilanes from Enals and β-Silyl Enones

T2 - Carbene Organocatalysis

AU - Zhang, Yuxia

AU - Huang, Jie

AU - Guo, Yingying

AU - Li, Lin

AU - Fu, Zhenqian

AU - Huang, Wei

PY - 2018/4/16

Y1 - 2018/4/16

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AB - Herein, an efficient route to enantioenriched organosilanes, containing two consecutive stereogenic centers, from enals and β-silyl enones under carbene organocatalysis is described. Under mild reaction conditions, this transition-metal-free strategy exhibits a broad substrate scope, and excellent diastereo- and enantioselectivity.

KW - cyclizations

KW - lactones

KW - N-heterocyclic carbenes

KW - organocatalysis

KW - silanes

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DO - 10.1002/anie.201800483

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Access to Enantioenriched Organosilanes from Enals and β-Silyl Enones: Carbene Organocatalysis

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Keywords

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