Solid-phase synthesis and self-assembly formation of tyrocidines

A facile and efficient method was applied for parallel total synthesis of natural cyclic decapeptides, tyrocidine A-E, on safty-catch resin. Synthetic products were equally active as the natural products isolated from the bacterial source and found to possess similar bacterial selectivity as other members in the amphipathic antimicrobial cyclic decapeptide family. At the same time, the self-assembling nanotubes of them were observed under a transmission electronic microscopy.