TY - JOUR
T1 - SIRT1
T2 - a potential tumour biomarker and therapeutic target
AU - Zhao, Bin
AU - Li, Xin
AU - Zhou, Liangfu
AU - Wang, Ye
AU - Shang, Peng
N1 - Publisher Copyright:
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2019/11/26
Y1 - 2019/11/26
N2 - SIRT1, which is highly homologous to yeast silent information regulator 2, has recently garnered tremendous attention because of its various regulatory effects in several pathological conditions. Numerous studies have found that SIRT1 is highly expressed in a broad range of tumours compared with the paracancerous tissue. However, the role of SIRT1 in malignancies has yet to be systematically elucidated, and its use as a promising biomarker or therapeutic target for tumours has not been well-reported. Herein, we focus on the roles of SIRT1 in cancers and summarise the potential use of SIRT1 as a promising tumour biomarker or therapeutic target.
AB - SIRT1, which is highly homologous to yeast silent information regulator 2, has recently garnered tremendous attention because of its various regulatory effects in several pathological conditions. Numerous studies have found that SIRT1 is highly expressed in a broad range of tumours compared with the paracancerous tissue. However, the role of SIRT1 in malignancies has yet to be systematically elucidated, and its use as a promising biomarker or therapeutic target for tumours has not been well-reported. Herein, we focus on the roles of SIRT1 in cancers and summarise the potential use of SIRT1 as a promising tumour biomarker or therapeutic target.
KW - SIRT1; tumour diagnosis; tumour prognosis; tumour biomarker; therapeutic target
UR - http://www.scopus.com/inward/record.url?scp=85072151482&partnerID=8YFLogxK
U2 - 10.1080/1061186X.2019.1605519
DO - 10.1080/1061186X.2019.1605519
M3 - 文献综述
C2 - 31056963
AN - SCOPUS:85072151482
SN - 1061-186X
VL - 27
SP - 1046
EP - 1052
JO - Journal of Drug Targeting
JF - Journal of Drug Targeting
IS - 10
ER -
