摘要
Monoamine oxidases have two functionally distinct but structurally similar isoforms (MAO-A and MAO-B). The ability to differentiate them by using fluorescence detection/imaging technology is of significant biological relevance, but highly challenging with available chemical tools. Herein, we report the first MAO-A-specific two-photon fluorogenic probe (F1), capable of selective imaging of endogenous MAO-A enzymatic activities from a variety of biological samples, including MAO-A-expressing neuronal SY-SY5Y cells, the brain of tumor-bearing mice and human Glioma tissues by using two-photon fluorescence microscopy (TPFM) with minimal cytotoxicity.
源语言 | 英语 |
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页(从-至) | 7536-7541 |
页数 | 6 |
期刊 | Angewandte Chemie - International Edition |
卷 | 59 |
期 | 19 |
DOI | |
出版状态 | 已出版 - 4 5月 2020 |