One-pot preparation of cross-linked amphiphilic fluorescent polymer based on aggregation induced emission dyes

Ke Wang, Xiaoyong Zhang, Xiqi Zhang, Bin Yang, Zhen Li, Qingsong Zhang, Zengfang Huang, Yen Wei

科研成果: 期刊稿件文章同行评审

24 引用 (Scopus)

摘要

Facile one-pot preparation of cross-linked amphiphilic fluorescent polymer based on aggregation induced emission (AIE) dyes and 2-isocyanatoethyl methacrylate (IM) has been developed. This was carried out first by free radical polymerization between AIE monomer (PhE) and IM, and then polyethyleneimine (PEI) was introduced to obtain the cross-linked fluorescent polymer. The resulted cross-linked amphiphilic polymer was prone to self-assemble into stable nanoparticles in aqueous solution with surplus amino groups on the surface which made them highly water dispersible and can be further functionalized. The as-prepared fluorescent polymer nanoparticles (PhE-IM-PEI FPNs) were fully characterized by a series of techniques including 1H NMR spectrum, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, dynamic light scattering, UV-vis absorption spectrum, and fluorescence spectra. Such FPNs demonstrated intense orange fluorescence with a high quantum yield of about 40%. Biocompatibility evaluation and cell uptake behavior of the nanoparticles were further investigated to explore their potential biomedical applications; the demonstrated excellent biocompatibility made them promising for cell imaging.

源语言英语
页(从-至)273-279
页数7
期刊Colloids and Surfaces B: Biointerfaces
126
DOI
出版状态已出版 - 1 2月 2015
已对外发布

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