TY - CHAP
T1 - Mechanobiology of bone marrow mesenchymal stem cells (BM-MSCs)
AU - Liu, Hua
AU - Tian, Zihan
AU - Liu, Shuyu
AU - Yang, Wenhui
AU - Qian, Airong
AU - Hu, Lifang
AU - Wu, Zixiang
N1 - Publisher Copyright:
© 2024 Elsevier Inc. All rights reserved.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - Bone marrow mesenchymal stem cells (BM-MSCs) are self-renewing cells with multidirectional differentiation potential. As the origin of osteogenic cell lineage, BM-MSCs are key cells involved in maintaining bone homeostasis and bone health. Research has illustrated the importance of mechanical stimuli in regulating the function of BM-MSCs. Mechanical loading, such as compression, tension forces, substrate stiffness (SS), fluid shear stress (FSS), hydrostatic pressure (HP), and vibration, promotes osteogenic differentiation of BM-MSCs, while mechanical unloading, such as prolonged bed rest, random positioning machine (RPM), and space flight, inhibits osteogenic differentiation of BM-MSCs, promoting adipogenic or chondrogenic differentiation. In this chapter, based on the brief introduction of the biological characteristics and functions of BM-MSCs, we present research on the mechanism of mechanical stimuli regulating differentiation of BM-MSCs.
AB - Bone marrow mesenchymal stem cells (BM-MSCs) are self-renewing cells with multidirectional differentiation potential. As the origin of osteogenic cell lineage, BM-MSCs are key cells involved in maintaining bone homeostasis and bone health. Research has illustrated the importance of mechanical stimuli in regulating the function of BM-MSCs. Mechanical loading, such as compression, tension forces, substrate stiffness (SS), fluid shear stress (FSS), hydrostatic pressure (HP), and vibration, promotes osteogenic differentiation of BM-MSCs, while mechanical unloading, such as prolonged bed rest, random positioning machine (RPM), and space flight, inhibits osteogenic differentiation of BM-MSCs, promoting adipogenic or chondrogenic differentiation. In this chapter, based on the brief introduction of the biological characteristics and functions of BM-MSCs, we present research on the mechanism of mechanical stimuli regulating differentiation of BM-MSCs.
KW - Bone marrow mesenchymal stem cells
KW - Differentiation
KW - Mechanical stimulation
KW - Mechanotransduction
KW - Signaling pathways
UR - http://www.scopus.com/inward/record.url?scp=85178015571&partnerID=8YFLogxK
U2 - 10.1016/B978-0-323-96123-3.00003-8
DO - 10.1016/B978-0-323-96123-3.00003-8
M3 - 章节
AN - SCOPUS:85178015571
SN - 9780323994842
SP - 97
EP - 124
BT - Bone Cell Biomechanics, Mechanobiology and Bone Diseases
PB - Elsevier
ER -