Mechanobiology of bone marrow mesenchymal stem cells (BM-MSCs)

Hua Liu, Zihan Tian, Shuyu Liu, Wenhui Yang, Airong Qian, Lifang Hu, Zixiang Wu

科研成果: 书/报告/会议事项章节章节同行评审

2 引用 (Scopus)

摘要

Bone marrow mesenchymal stem cells (BM-MSCs) are self-renewing cells with multidirectional differentiation potential. As the origin of osteogenic cell lineage, BM-MSCs are key cells involved in maintaining bone homeostasis and bone health. Research has illustrated the importance of mechanical stimuli in regulating the function of BM-MSCs. Mechanical loading, such as compression, tension forces, substrate stiffness (SS), fluid shear stress (FSS), hydrostatic pressure (HP), and vibration, promotes osteogenic differentiation of BM-MSCs, while mechanical unloading, such as prolonged bed rest, random positioning machine (RPM), and space flight, inhibits osteogenic differentiation of BM-MSCs, promoting adipogenic or chondrogenic differentiation. In this chapter, based on the brief introduction of the biological characteristics and functions of BM-MSCs, we present research on the mechanism of mechanical stimuli regulating differentiation of BM-MSCs.

源语言英语
主期刊名Bone Cell Biomechanics, Mechanobiology and Bone Diseases
出版商Elsevier
97-124
页数28
ISBN(电子版)9780323961233
ISBN(印刷版)9780323994842
DOI
出版状态已出版 - 1 1月 2023

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