Identifying drug-target interactions based on graph convolutional network and deep neural network

Tianyi Zhao, Yang Hu, Linda R. Valsdottir, Tianyi Zang, Jiajie Peng

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237 引用 (Scopus)

摘要

Identification of new drug-target interactions (DTIs) is an important but a time-consuming and costly step in drug discovery. In recent years, to mitigate these drawbacks, researchers have sought to identify DTIs using computational approaches. However, most existing methods construct drug networks and target networks separately, and then predict novel DTIs based on known associations between the drugs and targets without accounting for associations between drug-protein pairs (DPPs). To incorporate the associations between DPPs into DTI modeling, we built a DPP network based on multiple drugs and proteins in which DPPs are the nodes and the associations between DPPs are the edges of the network. We then propose a novel learning-based framework, 'graph convolutional network (GCN)-DTI', for DTI identification. The model first uses a graph convolutional network to learn the features for each DPP. Second, using the feature representation as an input, it uses a deep neural network to predict the final label. The results of our analysis show that the proposed framework outperforms some state-of-the-art approaches by a large margin.

源语言英语
页(从-至)2141-2150
页数10
期刊Briefings in Bioinformatics
22
2
DOI
出版状态已出版 - 1 3月 2021

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