Effect of imidacloprid on hepatotoxicity and nephrotoxicity in male albino mice

Yasir Arfat, Nasir Mahmood, Muhammad Usman Tahir, Maryam Rashid, Sameer Anjum, Fan Zhao, Di Jie Li, Yu Long Sun, Lifang Hu, Chen Zhihao, Chong Yin, Peng Shang, Ai Rong Qian

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102 引用 (Scopus)

摘要

Imidacloprid (IC) is a systemic insecticide related to the tobacco toxin nicotine. IC is a toxic substance frequently used into combat insects, rodents and plants pests and other creatures that can pose problems for agriculture. We, therefore, planned this study to assess risk factors, biochemical and histological alterations associated with hepatotoxicity and nephrotoxicity. Forty-eight adult male albino mice were divided into four groups of 12 animals each. All the animals were given standard synthetic pellet diet. One group served as control, and the other three were served as experimental groups. Decrease in the body weight of the high dose group was observed at 15mg/kg/day, and no mortality occurred during the treatment period. High dose of imidacloprid caused a significant elevation of serum clinical chemistry parameters, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvate kinase (SGPT), alkaline phosphatase (ALP) and total bilirubin (TBIL). Histology of liver and kidney indicates hepatotoxicity and nephrotoxicity at a high dose of imidacloprid. Based on the morphological, biochemical and histopathological analysis, it is evident that imidacloprid induced toxicological effects at 15mg/kg/day to mice. The results of the present study demonstrate that IC had significant effects on body weight, liver functions and kidney (p<0.05) at a dose of 15mg/kg body weight. IC treatment 5 and 10mg/kg/day may be considered as no observed adverse effect level (NOAEL) for mice. It was concluded that IC can cause hepatotoxicity and nephrotoxicity at a dose much lower than the LD50 (131mg/kg body weight) in mice.

源语言英语
页(从-至)554-561
页数8
期刊Toxicology Reports
1
DOI
出版状态已出版 - 20 8月 2014

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