Cellular resolution corneal imaging with extended imaging range

Lulu Wang, Qiaozhou Xiong, Xin Ge, En Bo, Jun Xie, Xinyu Liu, Xiaojun Yu, Xianghong Wang, Nanshuo Wang, Si Chen, Xuan Wu, Linbo Liu

科研成果: 期刊稿件文章同行评审

11 引用 (Scopus)

摘要

Current optical coherence tomography (OCT) technology, which is used for imaging the eye’s anterior segment, has been established as a clinical gold standard for the diagnosis of corneal diseases. However, the cellular resolution level information that is critical for many clinical applications is still not available. The major technical challenges toward cellular resolution OCT imaging are the limited ranging depth and depth of focus (DOF). In this work, we present a novel ultrahigh resolution OCT system that achieves an isotropic spatial resolution of <2 µm in tissue. The proposed system could approximately double the ranging depth and extend the DOF using the dual-spectrometer design and the forward-model based digital refocusing method, respectively. We demonstrate that the novel system is capable of visualizing the full thickness of the pig cornea over the ranging depth of 3.5 mm and the border of the corneal endothelial cells 8 times Rayleigh range away from the focal plane. This technology has the potential to realize cellular resolution corneal imaging in vivo.

源语言英语
页(从-至)1298-1309
页数12
期刊Optics Express
27
2
DOI
出版状态已出版 - 21 1月 2019

指纹

探究 'Cellular resolution corneal imaging with extended imaging range' 的科研主题。它们共同构成独一无二的指纹。

引用此