Autophagy-sensitized cytotoxicity of quantum dots in PC12 cells

Xiaoming Li; Nan Chen; Yuanyuan Su; Yao He; Min Yin; Min Wei; Lianhui Wang; Wei Huang; Chunhai Fan; Qing Huang

doi:10.1002/adhm.201300294

Autophagy-sensitized cytotoxicity of quantum dots in PC12 cells

Xiaoming Li, Nan Chen, Yuanyuan Su, Yao He, Min Yin, Min Wei, Lianhui Wang, Wei Huang, Chunhai Fan, Qing Huang

科研成果: 期刊稿件 › 文章 › 同行评审

48 引用（Scopus）

摘要

Both CdTe and CdTe/CdS/ZnS quantum dots induce similar levels of autophagy in PC12 and HEK293 cells, while the former exhibits higher toxicity. Low levels of cadmium ions are not sufficient to induce either autophagy or cytotoxicity by themselves. Interestingly, the combination of cadmium ions and CdTe/CdS/ZnS mimics the toxic effect of CdTe, suggesting that autophagy sensitizes cells to cadmium ions.

源语言	英语
页（从-至）	354-359
页数	6
期刊	Advanced Healthcare Materials
卷	3
期	3
DOI	https://doi.org/10.1002/adhm.201300294
出版状态	已出版 - 3月 2014
已对外发布	是

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10.1002/adhm.201300294

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title = "Autophagy-sensitized cytotoxicity of quantum dots in PC12 cells",

abstract = "Both CdTe and CdTe/CdS/ZnS quantum dots induce similar levels of autophagy in PC12 and HEK293 cells, while the former exhibits higher toxicity. Low levels of cadmium ions are not sufficient to induce either autophagy or cytotoxicity by themselves. Interestingly, the combination of cadmium ions and CdTe/CdS/ZnS mimics the toxic effect of CdTe, suggesting that autophagy sensitizes cells to cadmium ions.",

keywords = "Autophagy, Cadmium-based quantum dots, Cytotoxicity, Nanoscale effect",

author = "Xiaoming Li and Nan Chen and Yuanyuan Su and Yao He and Min Yin and Min Wei and Lianhui Wang and Wei Huang and Chunhai Fan and Qing Huang",

year = "2014",

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doi = "10.1002/adhm.201300294",

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T1 - Autophagy-sensitized cytotoxicity of quantum dots in PC12 cells

AU - Li, Xiaoming

AU - Chen, Nan

AU - Su, Yuanyuan

AU - He, Yao

AU - Yin, Min

AU - Wei, Min

AU - Wang, Lianhui

AU - Huang, Wei

AU - Fan, Chunhai

AU - Huang, Qing

PY - 2014/3

Y1 - 2014/3

N2 - Both CdTe and CdTe/CdS/ZnS quantum dots induce similar levels of autophagy in PC12 and HEK293 cells, while the former exhibits higher toxicity. Low levels of cadmium ions are not sufficient to induce either autophagy or cytotoxicity by themselves. Interestingly, the combination of cadmium ions and CdTe/CdS/ZnS mimics the toxic effect of CdTe, suggesting that autophagy sensitizes cells to cadmium ions.

AB - Both CdTe and CdTe/CdS/ZnS quantum dots induce similar levels of autophagy in PC12 and HEK293 cells, while the former exhibits higher toxicity. Low levels of cadmium ions are not sufficient to induce either autophagy or cytotoxicity by themselves. Interestingly, the combination of cadmium ions and CdTe/CdS/ZnS mimics the toxic effect of CdTe, suggesting that autophagy sensitizes cells to cadmium ions.

KW - Autophagy

KW - Cadmium-based quantum dots

KW - Cytotoxicity

KW - Nanoscale effect

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VL - 3

SP - 354

EP - 359

JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

IS - 3

ER -

Autophagy-sensitized cytotoxicity of quantum dots in PC12 cells

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