Analysis of the optimal target node to reduce seizure-like discharge in networks

Luyao Yan, Honghui Zhang, Zhongkui Sun

科研成果: 期刊稿件文章同行评审

1 引用 (Scopus)

摘要

Network approaches have been widely accepted to guide surgical strategy and predict outcome for epilepsy treatment. This study starts with a single oscillator to explore brain activity, using a phenomenological model capable of describing healthy and epileptic states. The ictal number of seizures decreases or remains unchanged with increasing the speed of oscillator excitability and in each seizure, there is an increasing tendency for ictal duration with respect to the speed. The underlying reason is that the strong excitability speed is conducive to reduce transition behaviors between two attractor basins. Moreover, the selection of the optimal removal node is estimated by an indicator proposed in this study. Results show that when the indicator is less than the threshold, removing the driving node is more possible to reduce seizures significantly, while the indicator exceeds the threshold, the epileptic node could be the removal one. Furthermore, the driving node is such a potential target that stimulating it is obviously effective in suppressing seizure-like activity compared to other nodes, and the propensity of seizures can be reduced 60% with the increased stimulus strength. Our results could provide new therapeutic ideas for epilepsy surgery and neuromodulation.

源语言英语
文章编号058703
期刊Chinese Physics B
33
5
DOI
出版状态已出版 - 1 5月 2024

指纹

探究 'Analysis of the optimal target node to reduce seizure-like discharge in networks' 的科研主题。它们共同构成独一无二的指纹。

引用此