A photopolymerized antimicrobial hydrogel coating derived from epsilon-poly-l-lysine

Chuncai Zhou; Peng Li; Xiaobao Qi; Abdul Rahim Mohamed Sharif; Yin Fun Poon; Ye Cao; Matthew W. Chang; Susanna Su Jan Leong; Mary B. Chan-Park

doi:10.1016/j.biomaterials.2010.12.040

A photopolymerized antimicrobial hydrogel coating derived from epsilon-poly-l-lysine

Chuncai Zhou, Peng Li, Xiaobao Qi, Abdul Rahim Mohamed Sharif, Yin Fun Poon, Ye Cao, Matthew W. Chang, Susanna Su Jan Leong, Mary B. Chan-Park

Nanyang Technological University

科研成果: 期刊稿件 › 文章 › 同行评审

226 引用（Scopus）

摘要

Hydrogels made from epsilon-poly- l-lysine-graft-methacrylamide (EPL-MA) have been found to have impressive wide spectrum antimicrobial activity against both bacteria (specifically Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens and Staphylococcus aureus) and fungi (specifically Candida albicans and Fusarium solani). The EPL-MA hydrogel also possesses in vitro biocompatibility and EPL-MA solution is relatively non-hemolytic: the concentration needed for onset of human red blood cell (hRBC) hemolysis is 12,500 μg/mL so that the selectivity for the pathogenic microorganisms over hRBCs is 230-1560. Further, EPL-MA hydrogel can be conveniently ultraviolet-immobilized onto plasma-treated plastic surfaces to form thin highly adherent antimicrobial hydrogel coatings for medical devices and implants.

源语言	英语
页（从-至）	2704-2712
页数	9
期刊	Biomaterials
卷	32
期	11
DOI	https://doi.org/10.1016/j.biomaterials.2010.12.040
出版状态	已出版 - 4月 2011
已对外发布	是

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title = "A photopolymerized antimicrobial hydrogel coating derived from epsilon-poly-l-lysine",

abstract = "Hydrogels made from epsilon-poly- l-lysine-graft-methacrylamide (EPL-MA) have been found to have impressive wide spectrum antimicrobial activity against both bacteria (specifically Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens and Staphylococcus aureus) and fungi (specifically Candida albicans and Fusarium solani). The EPL-MA hydrogel also possesses in vitro biocompatibility and EPL-MA solution is relatively non-hemolytic: the concentration needed for onset of human red blood cell (hRBC) hemolysis is 12,500 μg/mL so that the selectivity for the pathogenic microorganisms over hRBCs is 230-1560. Further, EPL-MA hydrogel can be conveniently ultraviolet-immobilized onto plasma-treated plastic surfaces to form thin highly adherent antimicrobial hydrogel coatings for medical devices and implants.",

keywords = "Antimicrobial peptide, Contact-active coating, Epsilon-poly-l-lysine, Graft, Hemolysis, Hydrogel",

author = "Chuncai Zhou and Peng Li and Xiaobao Qi and Sharif, {Abdul Rahim Mohamed} and Poon, {Yin Fun} and Ye Cao and Chang, {Matthew W.} and Leong, {Susanna Su Jan} and Chan-Park, {Mary B.}",

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doi = "10.1016/j.biomaterials.2010.12.040",

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AU - Zhou, Chuncai

AU - Li, Peng

AU - Qi, Xiaobao

AU - Sharif, Abdul Rahim Mohamed

AU - Poon, Yin Fun

AU - Cao, Ye

AU - Chang, Matthew W.

AU - Leong, Susanna Su Jan

AU - Chan-Park, Mary B.

PY - 2011/4

Y1 - 2011/4

N2 - Hydrogels made from epsilon-poly- l-lysine-graft-methacrylamide (EPL-MA) have been found to have impressive wide spectrum antimicrobial activity against both bacteria (specifically Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens and Staphylococcus aureus) and fungi (specifically Candida albicans and Fusarium solani). The EPL-MA hydrogel also possesses in vitro biocompatibility and EPL-MA solution is relatively non-hemolytic: the concentration needed for onset of human red blood cell (hRBC) hemolysis is 12,500 μg/mL so that the selectivity for the pathogenic microorganisms over hRBCs is 230-1560. Further, EPL-MA hydrogel can be conveniently ultraviolet-immobilized onto plasma-treated plastic surfaces to form thin highly adherent antimicrobial hydrogel coatings for medical devices and implants.

AB - Hydrogels made from epsilon-poly- l-lysine-graft-methacrylamide (EPL-MA) have been found to have impressive wide spectrum antimicrobial activity against both bacteria (specifically Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens and Staphylococcus aureus) and fungi (specifically Candida albicans and Fusarium solani). The EPL-MA hydrogel also possesses in vitro biocompatibility and EPL-MA solution is relatively non-hemolytic: the concentration needed for onset of human red blood cell (hRBC) hemolysis is 12,500 μg/mL so that the selectivity for the pathogenic microorganisms over hRBCs is 230-1560. Further, EPL-MA hydrogel can be conveniently ultraviolet-immobilized onto plasma-treated plastic surfaces to form thin highly adherent antimicrobial hydrogel coatings for medical devices and implants.

KW - Antimicrobial peptide

KW - Contact-active coating

KW - Epsilon-poly-l-lysine

KW - Graft

KW - Hemolysis

KW - Hydrogel

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U2 - 10.1016/j.biomaterials.2010.12.040

DO - 10.1016/j.biomaterials.2010.12.040

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AN - SCOPUS:79951579755

SN - 0142-9612

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SP - 2704

EP - 2712

JO - Biomaterials

JF - Biomaterials

IS - 11

ER -

A photopolymerized antimicrobial hydrogel coating derived from epsilon-poly-l-lysine

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