Synthesis of novel gold mesoflowers as SERS tags for immunoassay with improved sensitivity

Chunyuan Song; Linghua Min; Ni Zhou; Yanjun Yang; Shao Su; Wei Huang; Lianhui Wang

doi:10.1021/am502636h

Synthesis of novel gold mesoflowers as SERS tags for immunoassay with improved sensitivity

Chunyuan Song, Linghua Min, Ni Zhou, Yanjun Yang, Shao Su, Wei Huang, Lianhui Wang

Nanjing University of Posts and Telecommunications

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

A new class of flowerlike gold mesostructure in high yield is successfully synthesized through a facile one-step route using ascorbic acid as a reducing agent of gold salt with cetyltrimethylammonium chloride (CTAC) as surfactant. The as-prepared Au particles have spherical profiles with an averaged diameter of 770 ± 50 nm, but showing a highly rough surface consisting of many irregular and randomly arranged protrusions. The Au mesoflowers exhibit strong surface-enhanced effects and near-infrared absorption which were utilized in the design of efficient surface-enhanced Raman scattering (SERS) tags as immunosensors for immunoassay with improved sensitivity. The experimental results indicate that a good linear relationship is found between the peak intensity at 1071 cm^-1 and the logarithm of H-IgG concentration in the range between 1 ng/mL and 1 fg/mL, and the limit of detection (LOD) is 1 fg/mL.

Original language	English
Pages (from-to)	21842-21850
Number of pages	9
Journal	ACS Applied Materials and Interfaces
Volume	6
Issue number	24
DOIs	https://doi.org/10.1021/am502636h
State	Published - 24 Dec 2014
Externally published	Yes

Keywords

flowerlike gold mesostructures
immunoassay
SERS tags
surface-enhanced Raman scattering

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10.1021/am502636h

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title = "Synthesis of novel gold mesoflowers as SERS tags for immunoassay with improved sensitivity",

abstract = "A new class of flowerlike gold mesostructure in high yield is successfully synthesized through a facile one-step route using ascorbic acid as a reducing agent of gold salt with cetyltrimethylammonium chloride (CTAC) as surfactant. The as-prepared Au particles have spherical profiles with an averaged diameter of 770 ± 50 nm, but showing a highly rough surface consisting of many irregular and randomly arranged protrusions. The Au mesoflowers exhibit strong surface-enhanced effects and near-infrared absorption which were utilized in the design of efficient surface-enhanced Raman scattering (SERS) tags as immunosensors for immunoassay with improved sensitivity. The experimental results indicate that a good linear relationship is found between the peak intensity at 1071 cm-1 and the logarithm of H-IgG concentration in the range between 1 ng/mL and 1 fg/mL, and the limit of detection (LOD) is 1 fg/mL.",

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author = "Chunyuan Song and Linghua Min and Ni Zhou and Yanjun Yang and Shao Su and Wei Huang and Lianhui Wang",

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doi = "10.1021/am502636h",

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T1 - Synthesis of novel gold mesoflowers as SERS tags for immunoassay with improved sensitivity

AU - Song, Chunyuan

AU - Min, Linghua

AU - Zhou, Ni

AU - Yang, Yanjun

AU - Su, Shao

AU - Huang, Wei

AU - Wang, Lianhui

PY - 2014/12/24

Y1 - 2014/12/24

N2 - A new class of flowerlike gold mesostructure in high yield is successfully synthesized through a facile one-step route using ascorbic acid as a reducing agent of gold salt with cetyltrimethylammonium chloride (CTAC) as surfactant. The as-prepared Au particles have spherical profiles with an averaged diameter of 770 ± 50 nm, but showing a highly rough surface consisting of many irregular and randomly arranged protrusions. The Au mesoflowers exhibit strong surface-enhanced effects and near-infrared absorption which were utilized in the design of efficient surface-enhanced Raman scattering (SERS) tags as immunosensors for immunoassay with improved sensitivity. The experimental results indicate that a good linear relationship is found between the peak intensity at 1071 cm-1 and the logarithm of H-IgG concentration in the range between 1 ng/mL and 1 fg/mL, and the limit of detection (LOD) is 1 fg/mL.

AB - A new class of flowerlike gold mesostructure in high yield is successfully synthesized through a facile one-step route using ascorbic acid as a reducing agent of gold salt with cetyltrimethylammonium chloride (CTAC) as surfactant. The as-prepared Au particles have spherical profiles with an averaged diameter of 770 ± 50 nm, but showing a highly rough surface consisting of many irregular and randomly arranged protrusions. The Au mesoflowers exhibit strong surface-enhanced effects and near-infrared absorption which were utilized in the design of efficient surface-enhanced Raman scattering (SERS) tags as immunosensors for immunoassay with improved sensitivity. The experimental results indicate that a good linear relationship is found between the peak intensity at 1071 cm-1 and the logarithm of H-IgG concentration in the range between 1 ng/mL and 1 fg/mL, and the limit of detection (LOD) is 1 fg/mL.

KW - flowerlike gold mesostructures

KW - immunoassay

KW - SERS tags

KW - surface-enhanced Raman scattering

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U2 - 10.1021/am502636h

DO - 10.1021/am502636h

M3 - 文献综述

C2 - 25089331

AN - SCOPUS:84919935981

SN - 1944-8244

VL - 6

SP - 21842

EP - 21850

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 24

ER -

Synthesis of novel gold mesoflowers as SERS tags for immunoassay with improved sensitivity

Abstract

Keywords

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