Abstract
Backgroud: Pinoresinol (Pin) and pinoresinol monoglucoside (PMG) are plant-derived lignan molecules with multiple functions. We showed previously that an endophytic fungus from Eucommia ulmoides Oliv., Phomopsis sp. XP-8 is able to produce Pin and PMG. Objective: This study was carried out to test the anti-tumor capability of the culture of XP-8 and identify the major effective compounds. Method: The fungal culture was added in the culture of HepG2 and K562 cells, and the viabilities of these cells were detected and the possible mechanism was analyzed. Result: The fungal culture showed significant capaiblity in decreasing the viability of tumor cells and induce apoptosis via up-regulation of the expression of apoptosis-related genes. It also significantly inhibited the adhesion and migration of HepG2 cells by blocking MMP-9 expression. Pin and PMG were isolated from the growth culture and shown to be the major effective components for inhibition. Conclusion: The study indicated the potential application of XP-8 in the production of anti-tumour products by the bioconversion of glucose.
| Original language | English |
|---|---|
| Pages (from-to) | 982-989 |
| Number of pages | 8 |
| Journal | Anti-Cancer Agents in Medicinal Chemistry |
| Volume | 17 |
| Issue number | 7 |
| DOIs | |
| State | Published - 2017 |
Keywords
- Apoptosis
- Caspase
- Inhibition effects
- Pinoresinol
- Pinoresinol monoglucosid
