Iron metabolism gene expression and prognostic features of hepatocellular carcinoma

Ying Shen; Xin Li; Bin Zhao; Yanru Xue; Shenghang Wang; Xin Chen; Jiancheng Yang; Huanhuan Lv; Peng Shang

doi:10.1002/jcb.27184

Iron metabolism gene expression and prognostic features of hepatocellular carcinoma

Ying Shen, Xin Li, Bin Zhao, Yanru Xue, Shenghang Wang, Xin Chen, Jiancheng Yang, Huanhuan Lv, Peng Shang

School of life sciences

Northwestern Polytechnical University Xian

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Iron metabolism is crucial to hepatocellular carcinoma progression and is a key determinant of prognosis. Protein-protein interactions within the iron metabolism gene network were analyzed using the European Molecular Biology Laboratory's Search Tool for Recurring Instances of Neighbouring Genes/Proteins database. We obtained 423 liver hepatocellular carcinoma gene expression profiles from the Cancer Genome Atlas database. The expression and pathway enrichment of representative iron intake genes (TFRC and DMT1), utilization genes (FTH1, FTL, HIF1A, HMOX1, SLC25A37, and SLC25A38), and efflux genes (FLVCR1 and SLC40A1) was investigated in tumor and adjacent tissues. We determined the relationship between iron metabolism and the prognostic features of liver hepatocellular carcinoma. The liver metabolism genes TFRC and FLVCR1 were related to survival, disease status, and prognosis in patients with hepatocellular carcinoma. Our results provide novel insight into liver cancer therapy.

Original language	English
Pages (from-to)	9178-9204
Number of pages	27
Journal	Journal of Cellular Biochemistry
Volume	119
Issue number	11
DOIs	https://doi.org/10.1002/jcb.27184
State	Published - Nov 2018

Keywords

TCGA
bioinformatics
hepatocellular carcinoma (HCC)
iron metabolism
prognosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jcb.27184

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title = "Iron metabolism gene expression and prognostic features of hepatocellular carcinoma",

abstract = "Iron metabolism is crucial to hepatocellular carcinoma progression and is a key determinant of prognosis. Protein-protein interactions within the iron metabolism gene network were analyzed using the European Molecular Biology Laboratory's Search Tool for Recurring Instances of Neighbouring Genes/Proteins database. We obtained 423 liver hepatocellular carcinoma gene expression profiles from the Cancer Genome Atlas database. The expression and pathway enrichment of representative iron intake genes (TFRC and DMT1), utilization genes (FTH1, FTL, HIF1A, HMOX1, SLC25A37, and SLC25A38), and efflux genes (FLVCR1 and SLC40A1) was investigated in tumor and adjacent tissues. We determined the relationship between iron metabolism and the prognostic features of liver hepatocellular carcinoma. The liver metabolism genes TFRC and FLVCR1 were related to survival, disease status, and prognosis in patients with hepatocellular carcinoma. Our results provide novel insight into liver cancer therapy.",

keywords = "TCGA, bioinformatics, hepatocellular carcinoma (HCC), iron metabolism, prognosis",

author = "Ying Shen and Xin Li and Bin Zhao and Yanru Xue and Shenghang Wang and Xin Chen and Jiancheng Yang and Huanhuan Lv and Peng Shang",

note = "Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",

year = "2018",

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doi = "10.1002/jcb.27184",

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volume = "119",

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T1 - Iron metabolism gene expression and prognostic features of hepatocellular carcinoma

AU - Shen, Ying

AU - Li, Xin

AU - Zhao, Bin

AU - Xue, Yanru

AU - Wang, Shenghang

AU - Chen, Xin

AU - Yang, Jiancheng

AU - Lv, Huanhuan

AU - Shang, Peng

PY - 2018/11

Y1 - 2018/11

N2 - Iron metabolism is crucial to hepatocellular carcinoma progression and is a key determinant of prognosis. Protein-protein interactions within the iron metabolism gene network were analyzed using the European Molecular Biology Laboratory's Search Tool for Recurring Instances of Neighbouring Genes/Proteins database. We obtained 423 liver hepatocellular carcinoma gene expression profiles from the Cancer Genome Atlas database. The expression and pathway enrichment of representative iron intake genes (TFRC and DMT1), utilization genes (FTH1, FTL, HIF1A, HMOX1, SLC25A37, and SLC25A38), and efflux genes (FLVCR1 and SLC40A1) was investigated in tumor and adjacent tissues. We determined the relationship between iron metabolism and the prognostic features of liver hepatocellular carcinoma. The liver metabolism genes TFRC and FLVCR1 were related to survival, disease status, and prognosis in patients with hepatocellular carcinoma. Our results provide novel insight into liver cancer therapy.

AB - Iron metabolism is crucial to hepatocellular carcinoma progression and is a key determinant of prognosis. Protein-protein interactions within the iron metabolism gene network were analyzed using the European Molecular Biology Laboratory's Search Tool for Recurring Instances of Neighbouring Genes/Proteins database. We obtained 423 liver hepatocellular carcinoma gene expression profiles from the Cancer Genome Atlas database. The expression and pathway enrichment of representative iron intake genes (TFRC and DMT1), utilization genes (FTH1, FTL, HIF1A, HMOX1, SLC25A37, and SLC25A38), and efflux genes (FLVCR1 and SLC40A1) was investigated in tumor and adjacent tissues. We determined the relationship between iron metabolism and the prognostic features of liver hepatocellular carcinoma. The liver metabolism genes TFRC and FLVCR1 were related to survival, disease status, and prognosis in patients with hepatocellular carcinoma. Our results provide novel insight into liver cancer therapy.

KW - TCGA

KW - bioinformatics

KW - hepatocellular carcinoma (HCC)

KW - iron metabolism

KW - prognosis

UR - http://www.scopus.com/inward/record.url?scp=85052397566&partnerID=8YFLogxK

U2 - 10.1002/jcb.27184

DO - 10.1002/jcb.27184

M3 - 文章

C2 - 30076742

AN - SCOPUS:85052397566

SN - 0730-2312

VL - 119

SP - 9178

EP - 9204

JO - Journal of Cellular Biochemistry

JF - Journal of Cellular Biochemistry

IS - 11

ER -

Iron metabolism gene expression and prognostic features of hepatocellular carcinoma

Abstract

Keywords

UN SDGs

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