TY - GEN
T1 - Identification of Abnormal Cortical 3-Hinge Folding Patterns on Autism Spectral Brains
AU - Huang, Ying
AU - He, Zhibin
AU - Liu, Tianming
AU - Guo, Lei
AU - Zhang, Tuo
N1 - Publisher Copyright:
© Springer Nature Switzerland AG 2019.
PY - 2019
Y1 - 2019
N2 - Cortical folding has been demonstrated to be correlated with brain connective diagrams and functions. Identifying meaningful cortical folding patterns and landmarks could be valuable for understanding the relation between brain structure and function, the mechanism of brain organization. It also facilitates brain disease studies such as autism spectral disease (ASD), which in turn provides valuable clues to relate the abnormal folding morphology to abnormal brain function. Recently, a novel cortical folding pattern was identified, which is the conjunction of multiple gyri, termed as a gyral hinge. The uniqueness and importance of such a pattern lie in its maximal cortical thickness, axon density and functional complexity. However, the morphology of this pattern is not explicitly studied and related to brain structure and function on either healthy or diseased brains. In this study, we conduct a comparative MRI study between control group and ASD group in their gyral hinge morphology. The identified difference in morphology and spatial distribution is associated with the reported functional and cognitive differences. Our results demonstrate that gyral hinges could be related to brain functions on disease brains and used as potential predictors.
AB - Cortical folding has been demonstrated to be correlated with brain connective diagrams and functions. Identifying meaningful cortical folding patterns and landmarks could be valuable for understanding the relation between brain structure and function, the mechanism of brain organization. It also facilitates brain disease studies such as autism spectral disease (ASD), which in turn provides valuable clues to relate the abnormal folding morphology to abnormal brain function. Recently, a novel cortical folding pattern was identified, which is the conjunction of multiple gyri, termed as a gyral hinge. The uniqueness and importance of such a pattern lie in its maximal cortical thickness, axon density and functional complexity. However, the morphology of this pattern is not explicitly studied and related to brain structure and function on either healthy or diseased brains. In this study, we conduct a comparative MRI study between control group and ASD group in their gyral hinge morphology. The identified difference in morphology and spatial distribution is associated with the reported functional and cognitive differences. Our results demonstrate that gyral hinges could be related to brain functions on disease brains and used as potential predictors.
KW - Autism spectral disease
KW - Cortical morphology
KW - Gyral hinge
UR - http://www.scopus.com/inward/record.url?scp=85075583191&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-33226-6_7
DO - 10.1007/978-3-030-33226-6_7
M3 - 会议稿件
AN - SCOPUS:85075583191
SN - 9783030332259
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 57
EP - 65
BT - Multimodal Brain Image Analysis and Mathematical Foundations of Computational Anatomy - 4th International Workshop, MBIA 2019, and 7th International Workshop, MFCA 2019, Held in Conjunction with MICCAI 2019, Proceedings
A2 - Zhu, Dajiang
A2 - Yan, Jingwen
A2 - Huang, Heng
A2 - Shen, Li
A2 - Thompson, Paul M.
A2 - Westin, Carl-Fredrik
A2 - Pennec, Xavier
A2 - Joshi, Sarang
A2 - Nielsen, Mads
A2 - Sommer, Stefan
A2 - Fletcher, Tom
A2 - Durrleman, Stanley
PB - Springer
T2 - 4th International Workshop on Multimodal Brain Image Analysis, MBAI 2019, and the 7th International Workshop on Mathematical Foundations of Computational Anatomy, MFCA 2019, held in conjunction with the 22nd International Conference on Medical Imaging and Computer Assisted Intervention, MICCAI 2019
Y2 - 17 October 2019 through 17 October 2019
ER -