TY - GEN
T1 - Identification and characterization of lipopeptides as a potential wound healing agent produced by Bacillus subtilis
AU - Yan, Lu
AU - Liu, Guanwen
AU - Wang, Xinglong
AU - Jiang, Chunmei
AU - Shao, Dongyan
AU - Shi, Junling
N1 - Publisher Copyright:
© VDE VERLAG GMBH · Berlin · Offenbach.
PY - 2019
Y1 - 2019
N2 - Wound healing is an intricate and orchestrated process composed of inflammation, tissue formation, and remodeling phases, and is delayed in some cases, such as diabetes. Although some drugs have been applied to clinical use, the availability of drugs to promote the wound healing is required. Lipopeptides produced by Bacillus subtilis are famous for their antimicrobial activities, however, no report of lipopeptides has been found on affecting wound healing. The aim of our study is to determine the possibility of lipopeptides on wound healing. Results indicated that lipopeptides produced by B. subtilis markedly accelerated wound healing on the rabbit skin, and regulated inflammation reaction at the wound site by increasing the expression of TGF-β2 and IL-6. In conclusion, the function of lipopeptides might indicate the possibility of its clinical use for wound therapy.
AB - Wound healing is an intricate and orchestrated process composed of inflammation, tissue formation, and remodeling phases, and is delayed in some cases, such as diabetes. Although some drugs have been applied to clinical use, the availability of drugs to promote the wound healing is required. Lipopeptides produced by Bacillus subtilis are famous for their antimicrobial activities, however, no report of lipopeptides has been found on affecting wound healing. The aim of our study is to determine the possibility of lipopeptides on wound healing. Results indicated that lipopeptides produced by B. subtilis markedly accelerated wound healing on the rabbit skin, and regulated inflammation reaction at the wound site by increasing the expression of TGF-β2 and IL-6. In conclusion, the function of lipopeptides might indicate the possibility of its clinical use for wound therapy.
UR - http://www.scopus.com/inward/record.url?scp=85096511830&partnerID=8YFLogxK
M3 - 会议稿件
AN - SCOPUS:85096511830
T3 - 3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019
SP - 521
EP - 524
BT - 3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019
PB - VDE Verlag GmbH
T2 - 3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019
Y2 - 20 July 2019 through 22 July 2019
ER -
