Honey bee microRNAs respond to infection by the microsporidian parasite Nosema ceranae

Qiang Huang; Yanping Chen; Rui Wu Wang; Ryan S. Schwarz; Jay D. Evans

doi:10.1038/srep17494

Honey bee microRNAs respond to infection by the microsporidian parasite Nosema ceranae

Qiang Huang, Yanping Chen, Rui Wu Wang, Ryan S. Schwarz, Jay D. Evans

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

In order to study the effects of Nosema ceranae infection on honey bee microRNA (miRNA) expression, we deep-sequenced honey bee miRNAs daily across a full 6-day parasite reproduction cycle. Seventeen miRNAs were differentially expressed in honey bees infected by N. ceranae that potentially target over 400 genes predicted to primarily involve ion binding, signaling, the nucleus, transmembrane transport, and DNA binding. Based on Enzyme Code analysis, nine biological pathways were identified by screening target genes against the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, seven of which involved metabolism. Our results suggest that differentially expressed miRNAs regulate metabolism related genes of host honey bees in response to N. ceranae infection.

Original language	English
Article number	17494
Journal	Scientific Reports
Volume	5
DOIs	https://doi.org/10.1038/srep17494
State	Published - 1 Dec 2015
Externally published	Yes

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title = "Honey bee microRNAs respond to infection by the microsporidian parasite Nosema ceranae",

abstract = "In order to study the effects of Nosema ceranae infection on honey bee microRNA (miRNA) expression, we deep-sequenced honey bee miRNAs daily across a full 6-day parasite reproduction cycle. Seventeen miRNAs were differentially expressed in honey bees infected by N. ceranae that potentially target over 400 genes predicted to primarily involve ion binding, signaling, the nucleus, transmembrane transport, and DNA binding. Based on Enzyme Code analysis, nine biological pathways were identified by screening target genes against the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, seven of which involved metabolism. Our results suggest that differentially expressed miRNAs regulate metabolism related genes of host honey bees in response to N. ceranae infection.",

author = "Qiang Huang and Yanping Chen and Wang, {Rui Wu} and Schwarz, {Ryan S.} and Evans, {Jay D.}",

year = "2015",

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doi = "10.1038/srep17494",

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T1 - Honey bee microRNAs respond to infection by the microsporidian parasite Nosema ceranae

AU - Huang, Qiang

AU - Chen, Yanping

AU - Wang, Rui Wu

AU - Schwarz, Ryan S.

AU - Evans, Jay D.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - In order to study the effects of Nosema ceranae infection on honey bee microRNA (miRNA) expression, we deep-sequenced honey bee miRNAs daily across a full 6-day parasite reproduction cycle. Seventeen miRNAs were differentially expressed in honey bees infected by N. ceranae that potentially target over 400 genes predicted to primarily involve ion binding, signaling, the nucleus, transmembrane transport, and DNA binding. Based on Enzyme Code analysis, nine biological pathways were identified by screening target genes against the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, seven of which involved metabolism. Our results suggest that differentially expressed miRNAs regulate metabolism related genes of host honey bees in response to N. ceranae infection.

AB - In order to study the effects of Nosema ceranae infection on honey bee microRNA (miRNA) expression, we deep-sequenced honey bee miRNAs daily across a full 6-day parasite reproduction cycle. Seventeen miRNAs were differentially expressed in honey bees infected by N. ceranae that potentially target over 400 genes predicted to primarily involve ion binding, signaling, the nucleus, transmembrane transport, and DNA binding. Based on Enzyme Code analysis, nine biological pathways were identified by screening target genes against the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, seven of which involved metabolism. Our results suggest that differentially expressed miRNAs regulate metabolism related genes of host honey bees in response to N. ceranae infection.

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SN - 2045-2322

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JO - Scientific Reports

JF - Scientific Reports

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Honey bee microRNAs respond to infection by the microsporidian parasite Nosema ceranae

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