Fluorescent Metal Nanoclusters for Bioimaging

Because of their ultrasmall core size (usually <2 nm), strong photoluminescence, facile availability, and good biocompatibility, fluorescent metal nanoclusters (MNCs) have recently emerged as a novel kind of promising fluorescent probes for biological imaging. In this chapter, we will first provide an overview on recent advances in the development of various synthesis strategies for fluorescent MNCs. Then, we will summarize researches in the utilization of fluorescent MNCs (including Au, Ag, Cu, and alloy NCs) either as single-modal imaging probes or as multimodal imaging probes in biological cells and tissues. Finally, we will give a brief outlook on the future challenges and prospects of developing fluorescent MNCs for bioimaging at both in vitro and in vivo level.