Effect modification by aging on the associations of nicotine exposure with cognitive impairment among Chinese elderly

Jian Hou; Chao Huang; Bo Zhu; Wei Liu; Qing qing Zhu; Lu Wang; Tian Li; Chun jie Yuan; Shao yang Lai; De sheng Wu; Fei qi Zhu; Jia fei Zhang; Jia Huang; Er wei Gao; Yi dan Huang; Lu lin Nie; Shao you Lu; Xi fei Yang; Li Zhou; Fang Ye; Jing Yuan; Jian jun Liu

doi:10.1007/s11356-022-22392-3

Effect modification by aging on the associations of nicotine exposure with cognitive impairment among Chinese elderly

Jian Hou, Chao Huang, Bo Zhu, Wei Liu, Qing qing Zhu, Lu Wang, Tian Li, Chun jie Yuan, Shao yang Lai, De sheng Wu, Fei qi Zhu, Jia fei Zhang, Jia Huang, Er wei Gao, Yi dan Huang, Lu lin Nie, Shao you Lu, Xi fei Yang, Li Zhou, Fang YeJing Yuan, Jian jun Liu

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Active and passive exposure to tobacco smoke may increase risk of cognitive decline. However, effects of enhanced the aging process on the association of urinary nicotine metabolites with cognitive impairment remain unclear. In this study, 6657 Chinese older adults completed the physical examinations and cognitive tests. We measured urinary nicotine metabolite levels, mitochondrial DNA copy number (mtDNA-CN), and relative telomere length (RTL) and analyzed effects of urinary nicotine metabolites and their interaction with mtDNA-CN or RTL on cognitive impairment by generalized linear models and qg-computation, respectively. Each 1-unit increase in urinary 3-OHCot, 3-OHCotGluc, CotGluc, or NicGluc levels corresponded to a 1.05-, 1.09-, 1.04-, and 0.90-fold increased risk of cognitive impairment. Each 1-quantile increment in the mixture level of 8 nicotine metabolites corresponded to an increment of 1.40- and 1.34-fold risk of cognitive impairment in individuals with longer RTL or low mtDNA-CN. Urinary 3-OHCotGluc and RTL or mtDNA-CN exhibited an additive effect on cognitive impairment in addition to the mixture of 8 nicotine metabolites and mtDNA-CN. The findings suggested that aging process may increase the risk of tobacco-related cognitive impairment.

Original language	English
Pages (from-to)	9530-9542
Number of pages	13
Journal	Environmental Science and Pollution Research
Volume	30
Issue number	4
DOIs	https://doi.org/10.1007/s11356-022-22392-3
State	Published - Jan 2023
Externally published	Yes

Keywords

Additive effect
Mini-Mental State Examination
Nicotine
Quantile g-computation

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10.1007/s11356-022-22392-3

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Hou, J., Huang, C., Zhu, B., Liu, W., Zhu, Q. Q., Wang, L., Li, T., Yuan, C. J., Lai, S. Y., Wu, D. S., Zhu, F. Q., Zhang, J. F., Huang, J., Gao, E. W., Huang, Y. D., Nie, L. L., Lu, S. Y., Yang, X. F., Zhou, L., ... Liu, J. J. (2023). Effect modification by aging on the associations of nicotine exposure with cognitive impairment among Chinese elderly. Environmental Science and Pollution Research, 30(4), 9530-9542. https://doi.org/10.1007/s11356-022-22392-3

@article{11267f37a1bf43ea9cc9fcf17c0da9d1,

title = "Effect modification by aging on the associations of nicotine exposure with cognitive impairment among Chinese elderly",

abstract = "Active and passive exposure to tobacco smoke may increase risk of cognitive decline. However, effects of enhanced the aging process on the association of urinary nicotine metabolites with cognitive impairment remain unclear. In this study, 6657 Chinese older adults completed the physical examinations and cognitive tests. We measured urinary nicotine metabolite levels, mitochondrial DNA copy number (mtDNA-CN), and relative telomere length (RTL) and analyzed effects of urinary nicotine metabolites and their interaction with mtDNA-CN or RTL on cognitive impairment by generalized linear models and qg-computation, respectively. Each 1-unit increase in urinary 3-OHCot, 3-OHCotGluc, CotGluc, or NicGluc levels corresponded to a 1.05-, 1.09-, 1.04-, and 0.90-fold increased risk of cognitive impairment. Each 1-quantile increment in the mixture level of 8 nicotine metabolites corresponded to an increment of 1.40- and 1.34-fold risk of cognitive impairment in individuals with longer RTL or low mtDNA-CN. Urinary 3-OHCotGluc and RTL or mtDNA-CN exhibited an additive effect on cognitive impairment in addition to the mixture of 8 nicotine metabolites and mtDNA-CN. The findings suggested that aging process may increase the risk of tobacco-related cognitive impairment.",

keywords = "Additive effect, Mini-Mental State Examination, Nicotine, Quantile g-computation",

author = "Jian Hou and Chao Huang and Bo Zhu and Wei Liu and Zhu, {Qing qing} and Lu Wang and Tian Li and Yuan, {Chun jie} and Lai, {Shao yang} and Wu, {De sheng} and Zhu, {Fei qi} and Zhang, {Jia fei} and Jia Huang and Gao, {Er wei} and Huang, {Yi dan} and Nie, {Lu lin} and Lu, {Shao you} and Yang, {Xi fei} and Li Zhou and Fang Ye and Jing Yuan and Liu, {Jian jun}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2023",

month = jan,

doi = "10.1007/s11356-022-22392-3",

language = "英语",

volume = "30",

pages = "9530--9542",

journal = "Environmental Science and Pollution Research",

issn = "0944-1344",

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number = "4",

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Hou, J, Huang, C, Zhu, B, Liu, W, Zhu, QQ, Wang, L, Li, T, Yuan, CJ, Lai, SY, Wu, DS, Zhu, FQ, Zhang, JF, Huang, J, Gao, EW, Huang, YD, Nie, LL, Lu, SY, Yang, XF, Zhou, L, Ye, F, Yuan, J & Liu, JJ 2023, 'Effect modification by aging on the associations of nicotine exposure with cognitive impairment among Chinese elderly', Environmental Science and Pollution Research, vol. 30, no. 4, pp. 9530-9542. https://doi.org/10.1007/s11356-022-22392-3

TY - JOUR

T1 - Effect modification by aging on the associations of nicotine exposure with cognitive impairment among Chinese elderly

AU - Hou, Jian

AU - Huang, Chao

AU - Zhu, Bo

AU - Liu, Wei

AU - Zhu, Qing qing

AU - Wang, Lu

AU - Li, Tian

AU - Yuan, Chun jie

AU - Lai, Shao yang

AU - Wu, De sheng

AU - Zhu, Fei qi

AU - Zhang, Jia fei

AU - Huang, Jia

AU - Gao, Er wei

AU - Huang, Yi dan

AU - Nie, Lu lin

AU - Lu, Shao you

AU - Yang, Xi fei

AU - Zhou, Li

AU - Ye, Fang

AU - Yuan, Jing

AU - Liu, Jian jun

PY - 2023/1

Y1 - 2023/1

N2 - Active and passive exposure to tobacco smoke may increase risk of cognitive decline. However, effects of enhanced the aging process on the association of urinary nicotine metabolites with cognitive impairment remain unclear. In this study, 6657 Chinese older adults completed the physical examinations and cognitive tests. We measured urinary nicotine metabolite levels, mitochondrial DNA copy number (mtDNA-CN), and relative telomere length (RTL) and analyzed effects of urinary nicotine metabolites and their interaction with mtDNA-CN or RTL on cognitive impairment by generalized linear models and qg-computation, respectively. Each 1-unit increase in urinary 3-OHCot, 3-OHCotGluc, CotGluc, or NicGluc levels corresponded to a 1.05-, 1.09-, 1.04-, and 0.90-fold increased risk of cognitive impairment. Each 1-quantile increment in the mixture level of 8 nicotine metabolites corresponded to an increment of 1.40- and 1.34-fold risk of cognitive impairment in individuals with longer RTL or low mtDNA-CN. Urinary 3-OHCotGluc and RTL or mtDNA-CN exhibited an additive effect on cognitive impairment in addition to the mixture of 8 nicotine metabolites and mtDNA-CN. The findings suggested that aging process may increase the risk of tobacco-related cognitive impairment.

AB - Active and passive exposure to tobacco smoke may increase risk of cognitive decline. However, effects of enhanced the aging process on the association of urinary nicotine metabolites with cognitive impairment remain unclear. In this study, 6657 Chinese older adults completed the physical examinations and cognitive tests. We measured urinary nicotine metabolite levels, mitochondrial DNA copy number (mtDNA-CN), and relative telomere length (RTL) and analyzed effects of urinary nicotine metabolites and their interaction with mtDNA-CN or RTL on cognitive impairment by generalized linear models and qg-computation, respectively. Each 1-unit increase in urinary 3-OHCot, 3-OHCotGluc, CotGluc, or NicGluc levels corresponded to a 1.05-, 1.09-, 1.04-, and 0.90-fold increased risk of cognitive impairment. Each 1-quantile increment in the mixture level of 8 nicotine metabolites corresponded to an increment of 1.40- and 1.34-fold risk of cognitive impairment in individuals with longer RTL or low mtDNA-CN. Urinary 3-OHCotGluc and RTL or mtDNA-CN exhibited an additive effect on cognitive impairment in addition to the mixture of 8 nicotine metabolites and mtDNA-CN. The findings suggested that aging process may increase the risk of tobacco-related cognitive impairment.

KW - Additive effect

KW - Mini-Mental State Examination

KW - Nicotine

KW - Quantile g-computation

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U2 - 10.1007/s11356-022-22392-3

DO - 10.1007/s11356-022-22392-3

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C2 - 36057059

AN - SCOPUS:85137425699

SN - 0944-1344

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EP - 9542

JO - Environmental Science and Pollution Research

JF - Environmental Science and Pollution Research

IS - 4

ER -

Effect modification by aging on the associations of nicotine exposure with cognitive impairment among Chinese elderly

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Keywords

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