Effect modification by aging on the associations of nicotine exposure with cognitive impairment among Chinese elderly

Jian Hou, Chao Huang, Bo Zhu, Wei Liu, Qing qing Zhu, Lu Wang, Tian Li, Chun jie Yuan, Shao yang Lai, De sheng Wu, Fei qi Zhu, Jia fei Zhang, Jia Huang, Er wei Gao, Yi dan Huang, Lu lin Nie, Shao you Lu, Xi fei Yang, Li Zhou, Fang YeJing Yuan, Jian jun Liu

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Active and passive exposure to tobacco smoke may increase risk of cognitive decline. However, effects of enhanced the aging process on the association of urinary nicotine metabolites with cognitive impairment remain unclear. In this study, 6657 Chinese older adults completed the physical examinations and cognitive tests. We measured urinary nicotine metabolite levels, mitochondrial DNA copy number (mtDNA-CN), and relative telomere length (RTL) and analyzed effects of urinary nicotine metabolites and their interaction with mtDNA-CN or RTL on cognitive impairment by generalized linear models and qg-computation, respectively. Each 1-unit increase in urinary 3-OHCot, 3-OHCotGluc, CotGluc, or NicGluc levels corresponded to a 1.05-, 1.09-, 1.04-, and 0.90-fold increased risk of cognitive impairment. Each 1-quantile increment in the mixture level of 8 nicotine metabolites corresponded to an increment of 1.40- and 1.34-fold risk of cognitive impairment in individuals with longer RTL or low mtDNA-CN. Urinary 3-OHCotGluc and RTL or mtDNA-CN exhibited an additive effect on cognitive impairment in addition to the mixture of 8 nicotine metabolites and mtDNA-CN. The findings suggested that aging process may increase the risk of tobacco-related cognitive impairment.

Original languageEnglish
Pages (from-to)9530-9542
Number of pages13
JournalEnvironmental Science and Pollution Research
Volume30
Issue number4
DOIs
StatePublished - Jan 2023
Externally publishedYes

Keywords

  • Additive effect
  • Mini-Mental State Examination
  • Nicotine
  • Quantile g-computation

Fingerprint

Dive into the research topics of 'Effect modification by aging on the associations of nicotine exposure with cognitive impairment among Chinese elderly'. Together they form a unique fingerprint.

Cite this