Carbene-Catalyzed Construction of Carbazoles from Enals and 2-Methyl-3-oxoacetate Indoles

Dehai Liu; Yaru Gao; Jie Huang; Zhenqian Fu; Wei Huang

doi:10.1021/acs.joc.8b02532

Carbene-Catalyzed Construction of Carbazoles from Enals and 2-Methyl-3-oxoacetate Indoles

Dehai Liu, Yaru Gao, Jie Huang, Zhenqian Fu, Wei Huang

Institute of Flexible Electronics

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Direct and rapid construction of carbazoles has been successfully developed via carbene-catalyzed oxidative formal [4 + 2] annulation of enals with 2-methyl-3-oxoacetate indoles. This metal-free reaction features a broad substrate scope, features good functional-group tolerance, proceeds under mild conditions, and can be easily scaled up.

Original language	English
Pages (from-to)	14210-14217
Number of pages	8
Journal	Journal of Organic Chemistry
Volume	83
Issue number	22
DOIs	https://doi.org/10.1021/acs.joc.8b02532
State	Published - 16 Nov 2018

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title = "Carbene-Catalyzed Construction of Carbazoles from Enals and 2-Methyl-3-oxoacetate Indoles",

abstract = "Direct and rapid construction of carbazoles has been successfully developed via carbene-catalyzed oxidative formal [4 + 2] annulation of enals with 2-methyl-3-oxoacetate indoles. This metal-free reaction features a broad substrate scope, features good functional-group tolerance, proceeds under mild conditions, and can be easily scaled up.",

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AU - Liu, Dehai

AU - Gao, Yaru

AU - Huang, Jie

AU - Fu, Zhenqian

AU - Huang, Wei

PY - 2018/11/16

Y1 - 2018/11/16

N2 - Direct and rapid construction of carbazoles has been successfully developed via carbene-catalyzed oxidative formal [4 + 2] annulation of enals with 2-methyl-3-oxoacetate indoles. This metal-free reaction features a broad substrate scope, features good functional-group tolerance, proceeds under mild conditions, and can be easily scaled up.

AB - Direct and rapid construction of carbazoles has been successfully developed via carbene-catalyzed oxidative formal [4 + 2] annulation of enals with 2-methyl-3-oxoacetate indoles. This metal-free reaction features a broad substrate scope, features good functional-group tolerance, proceeds under mild conditions, and can be easily scaled up.

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SP - 14210

EP - 14217

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JF - Journal of Organic Chemistry

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ER -

Carbene-Catalyzed Construction of Carbazoles from Enals and 2-Methyl-3-oxoacetate Indoles

Abstract

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