TY - JOUR
T1 - Biopharmaceutical drug delivery and phototherapy using protein crystals
AU - Zhou, Renbin
AU - Qu, Jinghan
AU - Liu, Xuejiao
AU - Lin, Fangrui
AU - Ohulchanskyy, Tymish Y.
AU - Alifu, Nuernisha
AU - Qu, Junle
AU - Yin, Da Chuan
N1 - Publisher Copyright:
© 2024
PY - 2025/1
Y1 - 2025/1
N2 - Biopharmaceutical drugs, including proteins, peptides, and antibodies, are renowned for their high specificity and efficacy, fundamentally transforming disease treatment paradigms. However, their structural complexity presents challenges for their formulation and delivery. Protein crystals, characterized by high purity, high stability and a porous structure for biopharmaceutical drug encapsulation, providing a potential avenue for formulating and delivering biopharmaceutical drugs. There is increasing interest in engineering protein crystals to delivery biopharmaceutical drugs for biomedical applications. This review summarizes the recent advances in biopharmaceutical drug delivery and phototherapy using protein crystals. First, we evaluate the advantages of using protein crystals for biopharmaceutical drugs delivery. Next, we outline the strategies for in vitro and in vivo crystallization to prepare protein crystals. Importantly, the review highlights the advanced applications of protein crystals in biopharmaceutical drug delivery, tumor phototherapy, and other optical fields. Finally, it provides insights into future perspectives of biopharmaceutical drug delivery using protein crystals. This comprehensive review aims to provide effective insights into design of protein crystals to simplify biopharmaceutical drug delivery and improve disease treatment.
AB - Biopharmaceutical drugs, including proteins, peptides, and antibodies, are renowned for their high specificity and efficacy, fundamentally transforming disease treatment paradigms. However, their structural complexity presents challenges for their formulation and delivery. Protein crystals, characterized by high purity, high stability and a porous structure for biopharmaceutical drug encapsulation, providing a potential avenue for formulating and delivering biopharmaceutical drugs. There is increasing interest in engineering protein crystals to delivery biopharmaceutical drugs for biomedical applications. This review summarizes the recent advances in biopharmaceutical drug delivery and phototherapy using protein crystals. First, we evaluate the advantages of using protein crystals for biopharmaceutical drugs delivery. Next, we outline the strategies for in vitro and in vivo crystallization to prepare protein crystals. Importantly, the review highlights the advanced applications of protein crystals in biopharmaceutical drug delivery, tumor phototherapy, and other optical fields. Finally, it provides insights into future perspectives of biopharmaceutical drug delivery using protein crystals. This comprehensive review aims to provide effective insights into design of protein crystals to simplify biopharmaceutical drug delivery and improve disease treatment.
KW - Bio-imaging
KW - Biopharmaceutical drug formulation and delivery
KW - Drug carrier
KW - In vivo crystallization
KW - Phototherapy
KW - Protein crystal
UR - http://www.scopus.com/inward/record.url?scp=85210740477&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2024.115480
DO - 10.1016/j.addr.2024.115480
M3 - 文献综述
C2 - 39613032
AN - SCOPUS:85210740477
SN - 0169-409X
VL - 216
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
M1 - 115480
ER -