“A~A+B                         3                         ~” strategy to construct redox-responsive core-crosslinked copolymers as potential drug carrier

Shan Zhang; Fengbo Chen; Yiqing Yang; Heng Chen; Junjie Du; Jie Kong

doi:10.1016/j.reactfunctpolym.2019.03.001

“A~A+B ₃ ~” strategy to construct redox-responsive core-crosslinked copolymers as potential drug carrier

Shan Zhang, Fengbo Chen, Yiqing Yang, Heng Chen, Junjie Du, Jie Kong

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Redox-responsive core-crosslinked copolymers were synthesized based on poly(ε-caprolactone) (PCL) and poly(ethylene glycol) (PEG) via “A~A + B ₃ ~” strategy and Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. It is a feasible method for large-scale preparing redox-responsive core-crosslinked copolymers by crosslinking PCL-based disulfide bond-containing A-PCL-A macromonomers and PEG-based telechelic B ₃ ~ macromonomers. The core-crosslinked copolymers can form stable micelles through self-assembly in aqueous solution and exhibit reduction-cleavage responsibility in reductive medium. Further, their doxorubicin (DOX)-loaded micelles exhibit desirable reduction-triggered release performance in vitro. The cellular proliferation inhibition against A549 cells indicates their enhanced anticancer activity in comparison to free DOX. The redox-responsive core-crosslinked copolymers are expected to be used in smart delivery vehicles of anti-cancer drugs.

Original language	English
Pages (from-to)	122-128
Number of pages	7
Journal	Reactive and Functional Polymers
Volume	138
DOIs	https://doi.org/10.1016/j.reactfunctpolym.2019.03.001
State	Published - May 2019

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Zhang, S., Chen, F., Yang, Y., Chen, H., Du, J., & Kong, J. (2019). “A~A+B ₃ ~” strategy to construct redox-responsive core-crosslinked copolymers as potential drug carrier Reactive and Functional Polymers, 138, 122-128. https://doi.org/10.1016/j.reactfunctpolym.2019.03.001

@article{a218f13eb2e34a77b301f43eeef84056,

title = " “A~A+B 3 ~” strategy to construct redox-responsive core-crosslinked copolymers as potential drug carrier ",

abstract = " Redox-responsive core-crosslinked copolymers were synthesized based on poly(ε-caprolactone) (PCL) and poly(ethylene glycol) (PEG) via “A~A + B 3 ~” strategy and Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. It is a feasible method for large-scale preparing redox-responsive core-crosslinked copolymers by crosslinking PCL-based disulfide bond-containing A-PCL-A macromonomers and PEG-based telechelic B 3 ~ macromonomers. The core-crosslinked copolymers can form stable micelles through self-assembly in aqueous solution and exhibit reduction-cleavage responsibility in reductive medium. Further, their doxorubicin (DOX)-loaded micelles exhibit desirable reduction-triggered release performance in vitro. The cellular proliferation inhibition against A549 cells indicates their enhanced anticancer activity in comparison to free DOX. The redox-responsive core-crosslinked copolymers are expected to be used in smart delivery vehicles of anti-cancer drugs.",

author = "Shan Zhang and Fengbo Chen and Yiqing Yang and Heng Chen and Junjie Du and Jie Kong",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = may,

doi = "10.1016/j.reactfunctpolym.2019.03.001",

language = "英语",

volume = "138",

pages = "122--128",

journal = "Reactive and Functional Polymers",

issn = "1381-5148",

publisher = "Elsevier B.V.",

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Zhang, S, Chen, F, Yang, Y, Chen, H, Du, J & Kong, J 2019, ' “A~A+B ₃ ~” strategy to construct redox-responsive core-crosslinked copolymers as potential drug carrier ', Reactive and Functional Polymers, vol. 138, pp. 122-128. https://doi.org/10.1016/j.reactfunctpolym.2019.03.001

“A~A+B ₃ ~” strategy to construct redox-responsive core-crosslinked copolymers as potential drug carrier . / Zhang, Shan; Chen, Fengbo; Yang, Yiqing et al.
In: Reactive and Functional Polymers, Vol. 138, 05.2019, p. 122-128.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - “A~A+B 3 ~” strategy to construct redox-responsive core-crosslinked copolymers as potential drug carrier

AU - Zhang, Shan

AU - Chen, Fengbo

AU - Yang, Yiqing

AU - Chen, Heng

AU - Du, Junjie

AU - Kong, Jie

PY - 2019/5

Y1 - 2019/5

N2 - Redox-responsive core-crosslinked copolymers were synthesized based on poly(ε-caprolactone) (PCL) and poly(ethylene glycol) (PEG) via “A~A + B 3 ~” strategy and Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. It is a feasible method for large-scale preparing redox-responsive core-crosslinked copolymers by crosslinking PCL-based disulfide bond-containing A-PCL-A macromonomers and PEG-based telechelic B 3 ~ macromonomers. The core-crosslinked copolymers can form stable micelles through self-assembly in aqueous solution and exhibit reduction-cleavage responsibility in reductive medium. Further, their doxorubicin (DOX)-loaded micelles exhibit desirable reduction-triggered release performance in vitro. The cellular proliferation inhibition against A549 cells indicates their enhanced anticancer activity in comparison to free DOX. The redox-responsive core-crosslinked copolymers are expected to be used in smart delivery vehicles of anti-cancer drugs.

AB - Redox-responsive core-crosslinked copolymers were synthesized based on poly(ε-caprolactone) (PCL) and poly(ethylene glycol) (PEG) via “A~A + B 3 ~” strategy and Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. It is a feasible method for large-scale preparing redox-responsive core-crosslinked copolymers by crosslinking PCL-based disulfide bond-containing A-PCL-A macromonomers and PEG-based telechelic B 3 ~ macromonomers. The core-crosslinked copolymers can form stable micelles through self-assembly in aqueous solution and exhibit reduction-cleavage responsibility in reductive medium. Further, their doxorubicin (DOX)-loaded micelles exhibit desirable reduction-triggered release performance in vitro. The cellular proliferation inhibition against A549 cells indicates their enhanced anticancer activity in comparison to free DOX. The redox-responsive core-crosslinked copolymers are expected to be used in smart delivery vehicles of anti-cancer drugs.

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M3 - 文章

AN - SCOPUS:85063006420

SN - 1381-5148

VL - 138

SP - 122

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JO - Reactive and Functional Polymers

JF - Reactive and Functional Polymers

ER -

“A~A+B ₃ ~” strategy to construct redox-responsive core-crosslinked copolymers as potential drug carrier

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