A web tool for measuring gene semantic similarities by combining gene ontology and gene co-function networks

Jiajie Peng, Hongxiang Li, Yadong Wang, Jin Chen

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Gene Ontology(GO) is one of the most popular bioinformatic resource to study functional relationships between genes. However, the existing tools for calculating the semantic similarity are limited since they only rely on GO annotations and structure. We provide a working demonstration of a web tool that calculates functional similarities between GO terms by integrating gene co-function networks and information from GO. We demonstrate the function of the web tool by comparing remote GO terms. Copyright is held by the author/owner(s).

Original languageEnglish
Title of host publicationBCB 2015 - 6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics
PublisherAssociation for Computing Machinery, Inc
Pages678-679
Number of pages2
ISBN (Electronic)9781450338530
DOIs
StatePublished - 9 Sep 2015
Externally publishedYes
Event6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, BCB 2015 - Atlanta, United States
Duration: 9 Sep 201512 Sep 2015

Publication series

NameBCB 2015 - 6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics

Conference

Conference6th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, BCB 2015
Country/TerritoryUnited States
CityAtlanta
Period9/09/1512/09/15

Keywords

  • Gene ontology
  • Semantic similarity
  • Software tools

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