A Model for the Detection of Circulating Tumor Cells Based on Micro-OCT Imaging

Jinqian Lv, Chenlong Xue, Junfan Chen, Yaofei Jiang, Jiang Du, Junyu Wei, Hong Dang, Quan Tang, Han Wang, Hu Liang, Gina Jinna Chen, Xiaojun Yu, Yanqun Xiang, Perry Ping Shum

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Circulating tumor cells (CTCs) escape from the primary tumor site, then shed to the circulating system and travel around the body through the bloodstream before initiating metastatic tumors. However, CTCs in the circulatory system are rare, which makes it challenging to isolate and observe. Here, we aim to provide a feasible model to observe CTCs with high-resolution Optical Coherence Tomography (μOCT) in microfluidics, simulating the blood flow in vascular. CTCs are enriched and sorted by our microfluidic system. We obtained high-resolution CTCs' OCT images with the indication of fluorescent labeling for the data collection for real-time diagnostic system construction.

Original languageEnglish
Title of host publicationOGC 2023 - 8th Optoelectronics Global Conference
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages152-155
Number of pages4
ISBN (Electronic)9798350325324
DOIs
StatePublished - 2023
Event8th Optoelectronics Global Conference, OGC 2023 - Shenzhen, China
Duration: 5 Sep 20238 Sep 2023

Publication series

NameOGC 2023 - 8th Optoelectronics Global Conference

Conference

Conference8th Optoelectronics Global Conference, OGC 2023
Country/TerritoryChina
CityShenzhen
Period5/09/238/09/23

Keywords

  • Circulating tumor cells
  • Microfluidics
  • Optical Coherence Tomography

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