A facile flow-casting production of bioactive glass coatings on porous titanium for bone tissue engineering

Haiou Yang; Qijie Zhu; Hongfei Qi; Xianhu Liu; Meixia Ma; Qiang Chen

doi:10.3390/ma11091540

A facile flow-casting production of bioactive glass coatings on porous titanium for bone tissue engineering

Haiou Yang, Qijie Zhu, Hongfei Qi, Xianhu Liu, Meixia Ma, Qiang Chen

School of Materials Sience and Engineering

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Additive manufacturing enabled the fabrication of porous titanium (PT) with customized porosity and mechanical properties. However, functionalization of PT surfaces with bioactive coatings is being challenged due to sophisticated geometry and highly porous structure. In this study, a facile flow-casting technique was developed to produce homogeneous 45S5 bioactive glass (BG) coatings on the entire surface of PT. The coating weight as a function of BG concentration in a BG-PVA slurry was investigated to achieve controllable coating yield without blocking macropore structure. The annealing-treated BG coating not only exhibited compact adhesion confirmed by qualitative sonication treatment, but also enhanced the mechanical properties of PT scaffolds. Moreover, in-vitro assessments of BG-coated PT cultured with MC3T3-E1 cells was carried out having in mind their potential as bioactive bone implants. The experimental results in this study offer a simple and versatile approach for the bio-functionalization of PT and other porous biomedical devices.

Original language	English
Article number	1540
Journal	Materials
Volume	11
Issue number	9
DOIs	https://doi.org/10.3390/ma11091540
State	Published - 27 Aug 2018

Keywords

Bioactive glasses
Bone implant
Coating
Porous titanium

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10.3390/ma11091540

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title = "A facile flow-casting production of bioactive glass coatings on porous titanium for bone tissue engineering",

abstract = "Additive manufacturing enabled the fabrication of porous titanium (PT) with customized porosity and mechanical properties. However, functionalization of PT surfaces with bioactive coatings is being challenged due to sophisticated geometry and highly porous structure. In this study, a facile flow-casting technique was developed to produce homogeneous 45S5 bioactive glass (BG) coatings on the entire surface of PT. The coating weight as a function of BG concentration in a BG-PVA slurry was investigated to achieve controllable coating yield without blocking macropore structure. The annealing-treated BG coating not only exhibited compact adhesion confirmed by qualitative sonication treatment, but also enhanced the mechanical properties of PT scaffolds. Moreover, in-vitro assessments of BG-coated PT cultured with MC3T3-E1 cells was carried out having in mind their potential as bioactive bone implants. The experimental results in this study offer a simple and versatile approach for the bio-functionalization of PT and other porous biomedical devices.",

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author = "Haiou Yang and Qijie Zhu and Hongfei Qi and Xianhu Liu and Meixia Ma and Qiang Chen",

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T1 - A facile flow-casting production of bioactive glass coatings on porous titanium for bone tissue engineering

AU - Yang, Haiou

AU - Zhu, Qijie

AU - Qi, Hongfei

AU - Liu, Xianhu

AU - Ma, Meixia

AU - Chen, Qiang

PY - 2018/8/27

Y1 - 2018/8/27

N2 - Additive manufacturing enabled the fabrication of porous titanium (PT) with customized porosity and mechanical properties. However, functionalization of PT surfaces with bioactive coatings is being challenged due to sophisticated geometry and highly porous structure. In this study, a facile flow-casting technique was developed to produce homogeneous 45S5 bioactive glass (BG) coatings on the entire surface of PT. The coating weight as a function of BG concentration in a BG-PVA slurry was investigated to achieve controllable coating yield without blocking macropore structure. The annealing-treated BG coating not only exhibited compact adhesion confirmed by qualitative sonication treatment, but also enhanced the mechanical properties of PT scaffolds. Moreover, in-vitro assessments of BG-coated PT cultured with MC3T3-E1 cells was carried out having in mind their potential as bioactive bone implants. The experimental results in this study offer a simple and versatile approach for the bio-functionalization of PT and other porous biomedical devices.

AB - Additive manufacturing enabled the fabrication of porous titanium (PT) with customized porosity and mechanical properties. However, functionalization of PT surfaces with bioactive coatings is being challenged due to sophisticated geometry and highly porous structure. In this study, a facile flow-casting technique was developed to produce homogeneous 45S5 bioactive glass (BG) coatings on the entire surface of PT. The coating weight as a function of BG concentration in a BG-PVA slurry was investigated to achieve controllable coating yield without blocking macropore structure. The annealing-treated BG coating not only exhibited compact adhesion confirmed by qualitative sonication treatment, but also enhanced the mechanical properties of PT scaffolds. Moreover, in-vitro assessments of BG-coated PT cultured with MC3T3-E1 cells was carried out having in mind their potential as bioactive bone implants. The experimental results in this study offer a simple and versatile approach for the bio-functionalization of PT and other porous biomedical devices.

KW - Bioactive glasses

KW - Bone implant

KW - Coating

KW - Porous titanium

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A facile flow-casting production of bioactive glass coatings on porous titanium for bone tissue engineering

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Keywords

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