3-Substituted BINOL schiff bases and their reductive products for catalytic asymmetric addition of diethylzinc to aldehydes

Bing Liu; Zhi Bing Dong; Cao Fang; Hai Bin Song; Jin Shan Li

doi:10.1002/chir.20559

3-Substituted BINOL schiff bases and their reductive products for catalytic asymmetric addition of diethylzinc to aldehydes

Bing Liu, Zhi Bing Dong, Cao Fang, Hai Bin Song, Jin Shan Li

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Three new chiral 3-substituted BINOL Schiff bases and their reductive 3-arylaminomethylBINOL products have been synthesized and used for the asymmetric addition reaction of diethylzinc to aldehydes in the presence of titanium tetraisopropoxide. The reaction provided optically active secondary alcohols in high yield (86-100%) and good enantioselectivity (up to 92% ee).

Original language	English
Pages (from-to)	828-832
Number of pages	5
Journal	Chirality
Volume	20
Issue number	7
DOIs	https://doi.org/10.1002/chir.20559
State	Published - Jul 2008
Externally published	Yes

Keywords

Aldehyde
Asymmetric addition
BINOL
Schiff base
Titanium

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10.1002/chir.20559

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title = "3-Substituted BINOL schiff bases and their reductive products for catalytic asymmetric addition of diethylzinc to aldehydes",

abstract = "Three new chiral 3-substituted BINOL Schiff bases and their reductive 3-arylaminomethylBINOL products have been synthesized and used for the asymmetric addition reaction of diethylzinc to aldehydes in the presence of titanium tetraisopropoxide. The reaction provided optically active secondary alcohols in high yield (86-100%) and good enantioselectivity (up to 92% ee).",

keywords = "Aldehyde, Asymmetric addition, BINOL, Schiff base, Titanium",

author = "Bing Liu and Dong, {Zhi Bing} and Cao Fang and Song, {Hai Bin} and Li, {Jin Shan}",

year = "2008",

month = jul,

doi = "10.1002/chir.20559",

language = "英语",

volume = "20",

pages = "828--832",

journal = "Chirality",

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publisher = "Wiley-Liss Inc.",

number = "7",

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T1 - 3-Substituted BINOL schiff bases and their reductive products for catalytic asymmetric addition of diethylzinc to aldehydes

AU - Liu, Bing

AU - Dong, Zhi Bing

AU - Fang, Cao

AU - Song, Hai Bin

AU - Li, Jin Shan

PY - 2008/7

Y1 - 2008/7

N2 - Three new chiral 3-substituted BINOL Schiff bases and their reductive 3-arylaminomethylBINOL products have been synthesized and used for the asymmetric addition reaction of diethylzinc to aldehydes in the presence of titanium tetraisopropoxide. The reaction provided optically active secondary alcohols in high yield (86-100%) and good enantioselectivity (up to 92% ee).

AB - Three new chiral 3-substituted BINOL Schiff bases and their reductive 3-arylaminomethylBINOL products have been synthesized and used for the asymmetric addition reaction of diethylzinc to aldehydes in the presence of titanium tetraisopropoxide. The reaction provided optically active secondary alcohols in high yield (86-100%) and good enantioselectivity (up to 92% ee).

KW - Aldehyde

KW - Asymmetric addition

KW - BINOL

KW - Schiff base

KW - Titanium

UR - http://www.scopus.com/inward/record.url?scp=45849142569&partnerID=8YFLogxK

U2 - 10.1002/chir.20559

DO - 10.1002/chir.20559

M3 - 文章

C2 - 18338388

AN - SCOPUS:45849142569

SN - 0899-0042

VL - 20

SP - 828

EP - 832

JO - Chirality

JF - Chirality

IS - 7

ER -

3-Substituted BINOL schiff bases and their reductive products for catalytic asymmetric addition of diethylzinc to aldehydes

Abstract

Keywords

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