2-[(3-Carboxy-1-oxoprogy1) amino]-2-deoxy-D-glucose induces apoptosis in Hep G2 cells

Jing Wu; Delu Qi; Kou Wei; Juan Li; Xuan Chen; Aiqing Wang; Weiming Liu; Qunji Xue; Liang Qiao

2-[(3-Carboxy-1-oxoprogy1) amino]-2-deoxy-D-glucose induces apoptosis in Hep G2 cells

Jing Wu, Delu Qi, Kou Wei, Juan Li, Xuan Chen, Aiqing Wang, Weiming Liu, Qunji Xue, Liang Qiao

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Aim: To determine the effect of 2-[(3-carboxy-1-oxoprogy1) amino]-2-deoxy-D-glucose (COPADG) on proliferation and apoptosis of human hepatocellular carcinoma cells (Hep G2). Methods: Hep G2 cells were cultured in RPMI-1640 medium in the presence of various concentrations of COPADG. Cell proliferation was determined by MTT assay. Apoptosis was determined by fluorescence microscopy, transmission electron microscopy, agarose gel electrophoresis of DNA fragmentation, and flow cytometry. Results: At the concentration ranging between 1-30 μM, COPADG potently inhibits growth and induce apoptosis of Hep G2 cells. Conclusions: COPADG could effectively induce apoptosis in Hep G2 cells. It may be potentially useful as a new agent for treatment of human hepatocellular carcinoma.

Original language	English
Pages (from-to)	52-55
Number of pages	4
Journal	Experimental Oncology
Volume	27
Issue number	1
State	Published - Mar 2005
Externally published	Yes

Keywords

2-[(3-carboxy-1-oxoprogy1)amino]-2-deoxy-D- glucose
Apoptosis
COPADG
Hep G2
Hepatoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{f175e516b6de482a96b48db11dfc116a,

title = "2-[(3-Carboxy-1-oxoprogy1) amino]-2-deoxy-D-glucose induces apoptosis in Hep G2 cells",

abstract = "Aim: To determine the effect of 2-[(3-carboxy-1-oxoprogy1) amino]-2-deoxy-D-glucose (COPADG) on proliferation and apoptosis of human hepatocellular carcinoma cells (Hep G2). Methods: Hep G2 cells were cultured in RPMI-1640 medium in the presence of various concentrations of COPADG. Cell proliferation was determined by MTT assay. Apoptosis was determined by fluorescence microscopy, transmission electron microscopy, agarose gel electrophoresis of DNA fragmentation, and flow cytometry. Results: At the concentration ranging between 1-30 μM, COPADG potently inhibits growth and induce apoptosis of Hep G2 cells. Conclusions: COPADG could effectively induce apoptosis in Hep G2 cells. It may be potentially useful as a new agent for treatment of human hepatocellular carcinoma.",

keywords = "2-[(3-carboxy-1-oxoprogy1)amino]-2-deoxy-D- glucose, Apoptosis, COPADG, Hep G2, Hepatoma",

author = "Jing Wu and Delu Qi and Kou Wei and Juan Li and Xuan Chen and Aiqing Wang and Weiming Liu and Qunji Xue and Liang Qiao",

year = "2005",

month = mar,

language = "英语",

volume = "27",

pages = "52--55",

journal = "Experimental Oncology",

issn = "0204-3564",

number = "1",

}

TY - JOUR

T1 - 2-[(3-Carboxy-1-oxoprogy1) amino]-2-deoxy-D-glucose induces apoptosis in Hep G2 cells

AU - Wu, Jing

AU - Qi, Delu

AU - Wei, Kou

AU - Li, Juan

AU - Chen, Xuan

AU - Wang, Aiqing

AU - Liu, Weiming

AU - Xue, Qunji

AU - Qiao, Liang

PY - 2005/3

Y1 - 2005/3

N2 - Aim: To determine the effect of 2-[(3-carboxy-1-oxoprogy1) amino]-2-deoxy-D-glucose (COPADG) on proliferation and apoptosis of human hepatocellular carcinoma cells (Hep G2). Methods: Hep G2 cells were cultured in RPMI-1640 medium in the presence of various concentrations of COPADG. Cell proliferation was determined by MTT assay. Apoptosis was determined by fluorescence microscopy, transmission electron microscopy, agarose gel electrophoresis of DNA fragmentation, and flow cytometry. Results: At the concentration ranging between 1-30 μM, COPADG potently inhibits growth and induce apoptosis of Hep G2 cells. Conclusions: COPADG could effectively induce apoptosis in Hep G2 cells. It may be potentially useful as a new agent for treatment of human hepatocellular carcinoma.

AB - Aim: To determine the effect of 2-[(3-carboxy-1-oxoprogy1) amino]-2-deoxy-D-glucose (COPADG) on proliferation and apoptosis of human hepatocellular carcinoma cells (Hep G2). Methods: Hep G2 cells were cultured in RPMI-1640 medium in the presence of various concentrations of COPADG. Cell proliferation was determined by MTT assay. Apoptosis was determined by fluorescence microscopy, transmission electron microscopy, agarose gel electrophoresis of DNA fragmentation, and flow cytometry. Results: At the concentration ranging between 1-30 μM, COPADG potently inhibits growth and induce apoptosis of Hep G2 cells. Conclusions: COPADG could effectively induce apoptosis in Hep G2 cells. It may be potentially useful as a new agent for treatment of human hepatocellular carcinoma.

KW - 2-[(3-carboxy-1-oxoprogy1)amino]-2-deoxy-D- glucose

KW - Apoptosis

KW - COPADG

KW - Hep G2

KW - Hepatoma

UR - http://www.scopus.com/inward/record.url?scp=17444369361&partnerID=8YFLogxK

M3 - 文章

C2 - 15812358

AN - SCOPUS:17444369361

SN - 0204-3564

VL - 27

SP - 52

EP - 55

JO - Experimental Oncology

JF - Experimental Oncology

IS - 1

ER -

2-[(3-Carboxy-1-oxoprogy1) amino]-2-deoxy-D-glucose induces apoptosis in Hep G2 cells

Abstract

Keywords

UN SDGs

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