[12]aneN                         3                         -based lipid with naphthalimide moiety for enhanced gene transfection efficiency

Yong Guang Gao; Uzair Alam; Ai Xiang Ding; Quan Tang; Zheng Li Tan; You Di Shi; Zhong Lin Lu; Ai Rong Qian

doi:10.1016/j.bioorg.2018.04.018

[12]aneN ₃ -based lipid with naphthalimide moiety for enhanced gene transfection efficiency

Yong Guang Gao, Uzair Alam, Ai Xiang Ding, Quan Tang, Zheng Li Tan, You Di Shi, Zhong Lin Lu, Ai Rong Qian

School of life sciences

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Three cationic lipids derived from [12]aneN ₃ modified with naphthalimide (1a), oleic acid (1b) and octadecylamine (1c) were designed and synthesized. In vitro transfection showed that all these liposomes can deliver plasmid DNA into the tested cell lines. Among these liposomes, 1a gave the best transfection efficiency (TE) in A549 cells, which was higher than that of lipofectamine 2000. More importantly, the TE of 1a was dramatically increased in the presence of 10% serum. These results suggested that 1a might be a promising non-viral gene vector, and also give further insight for developing novel high performance gene delivery agents.

Original language	English
Pages (from-to)	334-340
Number of pages	7
Journal	Bioorganic Chemistry
Volume	79
DOIs	https://doi.org/10.1016/j.bioorg.2018.04.018
State	Published - Sep 2018

Keywords

Cationic lipids
Naphthalimide
Non-viral vectors
Transfection efficiency
[12]aneN3

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10.1016/j.bioorg.2018.04.018

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title = " [12]aneN 3 -based lipid with naphthalimide moiety for enhanced gene transfection efficiency ",

abstract = " Three cationic lipids derived from [12]aneN 3 modified with naphthalimide (1a), oleic acid (1b) and octadecylamine (1c) were designed and synthesized. In vitro transfection showed that all these liposomes can deliver plasmid DNA into the tested cell lines. Among these liposomes, 1a gave the best transfection efficiency (TE) in A549 cells, which was higher than that of lipofectamine 2000. More importantly, the TE of 1a was dramatically increased in the presence of 10% serum. These results suggested that 1a might be a promising non-viral gene vector, and also give further insight for developing novel high performance gene delivery agents.",

keywords = "Cationic lipids, Naphthalimide, Non-viral vectors, Transfection efficiency, [12]aneN3",

author = "Gao, {Yong Guang} and Uzair Alam and Ding, {Ai Xiang} and Quan Tang and Tan, {Zheng Li} and Shi, {You Di} and Lu, {Zhong Lin} and Qian, {Ai Rong}",

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year = "2018",

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doi = "10.1016/j.bioorg.2018.04.018",

language = "英语",

volume = "79",

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T1 - [12]aneN 3 -based lipid with naphthalimide moiety for enhanced gene transfection efficiency

AU - Gao, Yong Guang

AU - Alam, Uzair

AU - Ding, Ai Xiang

AU - Tang, Quan

AU - Tan, Zheng Li

AU - Shi, You Di

AU - Lu, Zhong Lin

AU - Qian, Ai Rong

PY - 2018/9

Y1 - 2018/9

N2 - Three cationic lipids derived from [12]aneN 3 modified with naphthalimide (1a), oleic acid (1b) and octadecylamine (1c) were designed and synthesized. In vitro transfection showed that all these liposomes can deliver plasmid DNA into the tested cell lines. Among these liposomes, 1a gave the best transfection efficiency (TE) in A549 cells, which was higher than that of lipofectamine 2000. More importantly, the TE of 1a was dramatically increased in the presence of 10% serum. These results suggested that 1a might be a promising non-viral gene vector, and also give further insight for developing novel high performance gene delivery agents.

AB - Three cationic lipids derived from [12]aneN 3 modified with naphthalimide (1a), oleic acid (1b) and octadecylamine (1c) were designed and synthesized. In vitro transfection showed that all these liposomes can deliver plasmid DNA into the tested cell lines. Among these liposomes, 1a gave the best transfection efficiency (TE) in A549 cells, which was higher than that of lipofectamine 2000. More importantly, the TE of 1a was dramatically increased in the presence of 10% serum. These results suggested that 1a might be a promising non-viral gene vector, and also give further insight for developing novel high performance gene delivery agents.

KW - Cationic lipids

KW - Naphthalimide

KW - Non-viral vectors

KW - Transfection efficiency

KW - [12]aneN3

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U2 - 10.1016/j.bioorg.2018.04.018

DO - 10.1016/j.bioorg.2018.04.018

M3 - 文章

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AN - SCOPUS:85047263294

SN - 0045-2068

VL - 79

SP - 334

EP - 340

JO - Bioorganic Chemistry

JF - Bioorganic Chemistry

ER -

[12]aneN ₃ -based lipid with naphthalimide moiety for enhanced gene transfection efficiency

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Keywords

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