Ventricle shape analysis for centenarians, elderly subjects, MCI and AD patients

Zhaojin Gong, Jianfeng Lu, Jia Chen, Yaping Wang, Yixuan Yuan, Tuo Zhang, Lei Guo, L. Stephen Miller

科研成果: 书/报告/会议事项章节会议稿件同行评审

4 引用 (Scopus)

摘要

In this paper, we examined the ventricle shapes of centenarian brains in comparison with those of elderly, mild cognitive impairment (MCI) and Alzheimer's Disease (AD). The MRI datasets obtained from Centenarian Study (CS) and the ADNI project are analyzed via the spherical harmonics (SPHARM) shape analysis pipeline. Our results indicate that if the elderly brains are used as comparison baseline, there is no significant difference between centenarian and elderly brains, while the differences between elderly and MCI/AD brains are significant; if the centenarian brains are used as comparison baseline, the differences between centenarian and MCI brains are moderate, but much more significant differences between AD and centenarian brains appear. Further comparisons of volume and shape analysis suggest that ventricle shape characteristics could potentially be a more sensitive biomarker of AD progression than the traditionally assumed ventricle volumes.

源语言英语
主期刊名Multimodal Brain Image Analysis - First International Workshop, MBIA 2011, Held in Conjunction with MICCAI 2011, Proceedings
84-92
页数9
DOI
出版状态已出版 - 2011
活动1st International Workshop on Multimodal Brain Image Analysis, MBIA 2011, in Conjunction with the 14th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2011 - Toronto, ON, 加拿大
期限: 18 9月 201118 9月 2011

出版系列

姓名Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
7012 LNCS
ISSN(印刷版)0302-9743
ISSN(电子版)1611-3349

会议

会议1st International Workshop on Multimodal Brain Image Analysis, MBIA 2011, in Conjunction with the 14th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2011
国家/地区加拿大
Toronto, ON
时期18/09/1118/09/11

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