@inproceedings{08ee9ba09e5e4ba4812c7e385bf1f90a,
title = "TSGOE: A web tool for tissue-specific gene ontology enrichment",
abstract = "Gene Ontology (GO) is one of the most popular Bioinformatics resources for studying the functional relationships between genes. GO enrichment analysis has become a routine method for gene function analysis, and it is of great significance for revealing the molecular mechanism of biology. However, existing GO enrichment analysis tools do not take into account tissue specificity and cannot distinguish gene sets that users interested. In this paper, we propose an easy-to-use web application, termed as TSGOE, which allows users to perform tissue specific-based GO enrichment analysis conveniently. Besides, TSGOE also provides rigorous statistical testing to improve the reliability of analytical result. To evaluate its performance, we apply TSGOE on several cancer-related gene lists. The experimental results show that our tool perform better than traditional GO enrichment analysis method. TSGOE is available at http://120.77.47.2:5678.",
keywords = "enrichment analysis, Gene Ontology, tissue-specific, web tool",
author = "Jiajie Peng and Guilin Lu and Hansheng Xue and Tao Wang and Xuequn Shang",
note = "Publisher Copyright: {\textcopyright} 2018 IEEE.; 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018 ; Conference date: 03-12-2018 Through 06-12-2018",
year = "2019",
month = jan,
day = "21",
doi = "10.1109/BIBM.2018.8621204",
language = "英语",
series = "Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "1266--1269",
editor = "Harald Schmidt and David Griol and Haiying Wang and Jan Baumbach and Huiru Zheng and Zoraida Callejas and Xiaohua Hu and Julie Dickerson and Le Zhang",
booktitle = "Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018",
}
