Transition metal-free approach to azafluoranthene scaffolds by aldol condensation/[1+2+3] annulation tandem reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes

Penghui Dong, Kashif Majeed, Lingna Wang, Zijian Guo, Fengtao Zhou, Qiuyu Zhang

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12 引用 (Scopus)

摘要

A transition metal-free aldol condensation/[1+2+3] annulation reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes has been developed for the general synthesis of azafluoranthenes. This domino reaction enables successive formation of three new bonds and two rings from readily accessible starting materials in a single operation. Furthermore, this methodology can also be utilized to construct chromeno[4,3-c]pyridines and benzo[c][2,6]naphthyridines in moderate yields.

源语言英语
页(从-至)4855-4858
页数4
期刊Chemical Communications
57
39
DOI
出版状态已出版 - 14 5月 2021

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