TY - JOUR
T1 - Therapeutic ionizing radiation induced bone loss
T2 - a review of in vivo and in vitro findings
AU - Zhang, Jian
AU - Qiu, Xinyu
AU - Xi, Kedi
AU - Hu, Wentao
AU - Pei, Hailong
AU - Nie, Jing
AU - Wang, Ziyang
AU - Ding, Jiahan
AU - Shang, Peng
AU - Li, Bingyan
AU - Zhou, Guangming
N1 - Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2018/11/2
Y1 - 2018/11/2
N2 - Radiation therapy is one of the routine treatment modalities for cancer patients. Ionizing radiation (IR) can induce bone loss, and consequently increases the risk of fractures with delayed and nonunion of the bone in the cancer patients who receive radiotherapy. The orchestrated bone remodeling can be disrupted due to the affected behaviors of bone cells, including bone mesenchymal stem cells (BMSCs), osteoblasts and osteoclasts. BMSCs and osteoblasts are relatively radioresistant compared with osteoclasts and its progenitors. Owing to different radiosensitivities of bone cells, unbalanced bone remodeling caused by IR is closely associated with the dose absorbed. For doses less than 2 Gy, osteoclastogenesis and adipogenesis by BMSCs are enhanced, while there are limited effects on osteoblasts. High doses (>10 Gy) induce disrupted architecture of bone, which is usually related to decreased osteogenic potential. In this review, studies elucidating the biological effects of IR on bone cells (BMSCs, osteoblasts and osteoclasts) are summarized. Several potential preventions and therapies are also proposed.
AB - Radiation therapy is one of the routine treatment modalities for cancer patients. Ionizing radiation (IR) can induce bone loss, and consequently increases the risk of fractures with delayed and nonunion of the bone in the cancer patients who receive radiotherapy. The orchestrated bone remodeling can be disrupted due to the affected behaviors of bone cells, including bone mesenchymal stem cells (BMSCs), osteoblasts and osteoclasts. BMSCs and osteoblasts are relatively radioresistant compared with osteoclasts and its progenitors. Owing to different radiosensitivities of bone cells, unbalanced bone remodeling caused by IR is closely associated with the dose absorbed. For doses less than 2 Gy, osteoclastogenesis and adipogenesis by BMSCs are enhanced, while there are limited effects on osteoblasts. High doses (>10 Gy) induce disrupted architecture of bone, which is usually related to decreased osteogenic potential. In this review, studies elucidating the biological effects of IR on bone cells (BMSCs, osteoblasts and osteoclasts) are summarized. Several potential preventions and therapies are also proposed.
KW - Bone loss
KW - bone mesenchymal stem cells
KW - osteoblasts
KW - osteoclasts
KW - radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=85055620351&partnerID=8YFLogxK
U2 - 10.1080/03008207.2018.1439482
DO - 10.1080/03008207.2018.1439482
M3 - 文献综述
C2 - 29448860
AN - SCOPUS:85055620351
SN - 0300-8207
VL - 59
SP - 509
EP - 522
JO - Connective Tissue Research
JF - Connective Tissue Research
IS - 6
ER -