TY - JOUR
T1 - The Application of MSCs-Derived Extracellular Vesicles in Bone Disorders
T2 - Novel Cell-Free Therapeutic Strategy
AU - Liu, Shuyu
AU - Xu, Xia
AU - Liang, Shujing
AU - Chen, Zhihao
AU - Zhang, Yan
AU - Qian, Airong
AU - Hu, Lifang
N1 - Publisher Copyright:
© Copyright © 2020 Liu, Xu, Liang, Chen, Zhang, Qian and Hu.
PY - 2020/7/22
Y1 - 2020/7/22
N2 - Bone is crucial for supporting the body, protecting other organs, providing minerals, and secreting hormone to regulate other organ’s function. Bone disorders result in pain and disability, severely affecting human health, reducing the quality of life and increasing costs to society. With the rapid increase in the aging population worldwide, bone disorders have become one major disease. As a result, efficacious therapies of bone disorders have become the focus of attention worldwide. Mesenchymal stem cells (MSCs) have been widely explored as a new therapeutic method for numerous diseases. Recent evidence suggests that the therapeutic effects of MSCs are mainly mediated by their extracellular vesicles (EV). MSCs-derived extracellular vesicles (MSCs-EV) is indicated as a novel cell-free alternative to cell therapy with MSCs in regenerative medicine. Here, we review the current knowledge of EV and highlight the application studies of MSCs-EV in bone disorders by focusing on osteoarthritis (OA), rheumatoid arthritis (RA), osteoporosis (OP), and bone fracture. Moreover, we discuss the key issues and perspectives of MSCs-EV as a clinical therapeutic strategy for bone diseases.
AB - Bone is crucial for supporting the body, protecting other organs, providing minerals, and secreting hormone to regulate other organ’s function. Bone disorders result in pain and disability, severely affecting human health, reducing the quality of life and increasing costs to society. With the rapid increase in the aging population worldwide, bone disorders have become one major disease. As a result, efficacious therapies of bone disorders have become the focus of attention worldwide. Mesenchymal stem cells (MSCs) have been widely explored as a new therapeutic method for numerous diseases. Recent evidence suggests that the therapeutic effects of MSCs are mainly mediated by their extracellular vesicles (EV). MSCs-derived extracellular vesicles (MSCs-EV) is indicated as a novel cell-free alternative to cell therapy with MSCs in regenerative medicine. Here, we review the current knowledge of EV and highlight the application studies of MSCs-EV in bone disorders by focusing on osteoarthritis (OA), rheumatoid arthritis (RA), osteoporosis (OP), and bone fracture. Moreover, we discuss the key issues and perspectives of MSCs-EV as a clinical therapeutic strategy for bone diseases.
KW - bone fracture
KW - exosomes
KW - extracellular vesicles
KW - mesenchymal stem cells
KW - osteoarthritis
KW - osteoporosis
KW - rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=85089072079&partnerID=8YFLogxK
U2 - 10.3389/fcell.2020.00619
DO - 10.3389/fcell.2020.00619
M3 - 文献综述
AN - SCOPUS:85089072079
SN - 2296-634X
VL - 8
JO - Frontiers in Cell and Developmental Biology
JF - Frontiers in Cell and Developmental Biology
M1 - 619
ER -