Telomere reverse transcriptase (TERT) rs2735940 increases cancer risk

Hui Yang, Jing Li, Ruihua Tang, Yaxiong Liu, Yan Shao, Qingsheng Huang, Junling Shi

科研成果: 期刊稿件文章同行评审

8 引用 (Scopus)

摘要

Background: Telomerase reverse transcriptase (TERT) rs2735940 polymorphism was found to be associated with increased cancer risk. However, recent studies reported controversial results. The aim of our study was to detect its relationship with cancer risk. Material/Methods: EMBASE and PubMed databases were searched for all publications until October 2014. ORs and 95% CIs were applied to investigate the association in the random-effects model. Results: Thirteen case-control studies with 19385 cases and 17558 controls were included in this study. We found a significant association between cancer risk and TERT rs2735940 polymorphism (OR=1.06, 95% CI 1.02–1.11, P=0.005). In the subgroup analysis by ethnicity, a marginal association was found in Caucasians (OR=1.05, 95% CI 1.00–1.10, P=0.05), but not in Asians (OR=1.01, 95% CI 0.82–1.24, P=0.93). In the subgroup analysis by cancer site, this polymorphism was significantly associated with lung cancer risk (OR=1.08, 95% CI 1.02–1.13, P=0.004). Conclusions: TERT rs2735940 polymorphism was significantly associated with cancer risk, especially lung cancer.

源语言英语
页(从-至)612-616
页数5
期刊Medical Science Monitor
21
DOI
出版状态已出版 - 26 2月 2015

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