Synthesis, characterization and cytotoxicity of some triarylbismuth(V) di(N-p-toluenesulfonyl) aminoacetates and the crystal structure of (4-CH 3C6H4SO2NHCH2CO 2)2Bi(C6H4Cl-4)3

Lin Yu; Yong Qiang Ma; Guo Cang Wang; Hai Bin Song; Hong Geng Wang; Jin Shan Li; Jing Rong Cui; Rui Qing Wang

doi:10.1002/aoc.609

Synthesis, characterization and cytotoxicity of some triarylbismuth(V) di(N-p-toluenesulfonyl) aminoacetates and the crystal structure of (4-CH ₃C₆H₄SO₂NHCH₂CO ₂)₂Bi(C₆H₄Cl-4)₃

Lin Yu, Yong Qiang Ma, Guo Cang Wang, Hai Bin Song, Hong Geng Wang, Jin Shan Li, Jing Rong Cui, Rui Qing Wang

科研成果: 期刊稿件 › 文章 › 同行评审

10 引用（Scopus）

摘要

A series of triarylbismuth(V) di(N-p-toluenesulfonyl)aminoacetates with the formula (4-CH₃C₆H₄SO₂ NHCH ₂CO₂)₂BiAr₃ (Ar=C₆H ₅, 4-CH₃C₆H₄, 4-ClC ₆H₄, 4-BrC₆H₄) were synthesized and characterized by elemental analysis, IR, ¹H NMR and mass spectra. The crystal structure of (4-CH₃C₆H₄SO ₂NHCH₂CO₂)₂Bi(C₆H ₄Cl-4)₃ was determined and shows the bismuth to exist in a distorted trigonal bipyramidal geometry. Four human neoplastic cell lines (HL-60, PC-3MIE8, BGC-823 and MDA-MB-435) were used to screen these compounds. The results indicate that these compounds at 10 μM show cytotoxicity.

源语言	英语
页（从-至）	187-190
页数	4
期刊	Applied Organometallic Chemistry
卷	18
期	4
DOI	https://doi.org/10.1002/aoc.609
出版状态	已出版 - 4月 2004
已对外发布	是

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title = "Synthesis, characterization and cytotoxicity of some triarylbismuth(V) di(N-p-toluenesulfonyl) aminoacetates and the crystal structure of (4-CH 3C6H4SO2NHCH2CO 2)2Bi(C6H4Cl-4)3",

abstract = "A series of triarylbismuth(V) di(N-p-toluenesulfonyl)aminoacetates with the formula (4-CH3C6H4SO2 NHCH 2CO2)2BiAr3 (Ar=C6H 5, 4-CH3C6H4, 4-ClC 6H4, 4-BrC6H4) were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectra. The crystal structure of (4-CH3C6H4SO 2NHCH2CO2)2Bi(C6H 4Cl-4)3 was determined and shows the bismuth to exist in a distorted trigonal bipyramidal geometry. Four human neoplastic cell lines (HL-60, PC-3MIE8, BGC-823 and MDA-MB-435) were used to screen these compounds. The results indicate that these compounds at 10 μM show cytotoxicity.",

keywords = "Antitumor activity, Arylbismuth, Crystal structure",

author = "Lin Yu and Ma, {Yong Qiang} and Wang, {Guo Cang} and Song, {Hai Bin} and Wang, {Hong Geng} and Li, {Jin Shan} and Cui, {Jing Rong} and Wang, {Rui Qing}",

year = "2004",

month = apr,

doi = "10.1002/aoc.609",

language = "英语",

volume = "18",

pages = "187--190",

journal = "Applied Organometallic Chemistry",

issn = "0268-2605",

publisher = "John Wiley and Sons Ltd",

number = "4",

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TY - JOUR

T1 - Synthesis, characterization and cytotoxicity of some triarylbismuth(V) di(N-p-toluenesulfonyl) aminoacetates and the crystal structure of (4-CH 3C6H4SO2NHCH2CO 2)2Bi(C6H4Cl-4)3

AU - Yu, Lin

AU - Ma, Yong Qiang

AU - Wang, Guo Cang

AU - Song, Hai Bin

AU - Wang, Hong Geng

AU - Li, Jin Shan

AU - Cui, Jing Rong

AU - Wang, Rui Qing

PY - 2004/4

Y1 - 2004/4

N2 - A series of triarylbismuth(V) di(N-p-toluenesulfonyl)aminoacetates with the formula (4-CH3C6H4SO2 NHCH 2CO2)2BiAr3 (Ar=C6H 5, 4-CH3C6H4, 4-ClC 6H4, 4-BrC6H4) were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectra. The crystal structure of (4-CH3C6H4SO 2NHCH2CO2)2Bi(C6H 4Cl-4)3 was determined and shows the bismuth to exist in a distorted trigonal bipyramidal geometry. Four human neoplastic cell lines (HL-60, PC-3MIE8, BGC-823 and MDA-MB-435) were used to screen these compounds. The results indicate that these compounds at 10 μM show cytotoxicity.

AB - A series of triarylbismuth(V) di(N-p-toluenesulfonyl)aminoacetates with the formula (4-CH3C6H4SO2 NHCH 2CO2)2BiAr3 (Ar=C6H 5, 4-CH3C6H4, 4-ClC 6H4, 4-BrC6H4) were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectra. The crystal structure of (4-CH3C6H4SO 2NHCH2CO2)2Bi(C6H 4Cl-4)3 was determined and shows the bismuth to exist in a distorted trigonal bipyramidal geometry. Four human neoplastic cell lines (HL-60, PC-3MIE8, BGC-823 and MDA-MB-435) were used to screen these compounds. The results indicate that these compounds at 10 μM show cytotoxicity.

KW - Antitumor activity

KW - Arylbismuth

KW - Crystal structure

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U2 - 10.1002/aoc.609

DO - 10.1002/aoc.609

M3 - 文章

AN - SCOPUS:1842576876

SN - 0268-2605

VL - 18

SP - 187

EP - 190

JO - Applied Organometallic Chemistry

JF - Applied Organometallic Chemistry

IS - 4

ER -

Synthesis, characterization and cytotoxicity of some triarylbismuth(V) di(N-p-toluenesulfonyl) aminoacetates and the crystal structure of (4-CH 3C6H4SO2NHCH2CO 2)2Bi(C6H4Cl-4)3

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Synthesis, characterization and cytotoxicity of some triarylbismuth(V) di(N-p-toluenesulfonyl) aminoacetates and the crystal structure of (4-CH ₃C₆H₄SO₂NHCH₂CO ₂)₂Bi(C₆H₄Cl-4)₃