TY - JOUR
T1 - Sulfur-Doped NiFe Hydroxide Nanobowls with Wrinkling Patterns for Photothermal Cancer Therapy
AU - Zhang, Yuxuan
AU - Wang, Teng
AU - Hu, Renquan
AU - Qing, Guangchao
AU - Gong, Ningqiang
AU - Yang, Yong
AU - Liang, Xing Jie
N1 - Publisher Copyright:
© 2023 American Chemical Society.
PY - 2023/10/24
Y1 - 2023/10/24
N2 - Hierarchical multiscale wrinkling nanostructures have shown great promise for many biomedical applications, such as cancer diagnosis and therapy. However, synthesizing these materials with precise control remains challenging. Here, we report a sulfur doping strategy to synthesize sub-1 nm NiFe hydroxide ultrathin nanosheets (S-NiFe HUNs). The introduction of sulfur affects the reduction of the band gap and the adjustment of the electronic structure, thereby improving the light absorption ability of the S-NiFe HUNs. Additionally, S-NiFe HUNs show a multilayered nanobowl-like structure that enables multiple reflections of incident light inside the nanostructure, which improved the utilization of incident light and achieved high photothermal conversion. As a result, the as-prepared product with hydrophilic modification (dS-NiFe HUNs) demonstrated enhanced tumor-killing ability in vitro. In a mouse model of breast cancer, dS-NiFe HUNs combined with near-infrared light irradiation greatly inhibited tumor growth and prolonged the mice survival. Altogether, our study demonstrates the great potential of dS-NiFe HUNs for cancer photothermal therapy applications.
AB - Hierarchical multiscale wrinkling nanostructures have shown great promise for many biomedical applications, such as cancer diagnosis and therapy. However, synthesizing these materials with precise control remains challenging. Here, we report a sulfur doping strategy to synthesize sub-1 nm NiFe hydroxide ultrathin nanosheets (S-NiFe HUNs). The introduction of sulfur affects the reduction of the band gap and the adjustment of the electronic structure, thereby improving the light absorption ability of the S-NiFe HUNs. Additionally, S-NiFe HUNs show a multilayered nanobowl-like structure that enables multiple reflections of incident light inside the nanostructure, which improved the utilization of incident light and achieved high photothermal conversion. As a result, the as-prepared product with hydrophilic modification (dS-NiFe HUNs) demonstrated enhanced tumor-killing ability in vitro. In a mouse model of breast cancer, dS-NiFe HUNs combined with near-infrared light irradiation greatly inhibited tumor growth and prolonged the mice survival. Altogether, our study demonstrates the great potential of dS-NiFe HUNs for cancer photothermal therapy applications.
KW - doping strategy
KW - multiscale wrinkling structures
KW - NiFe hydroxide
KW - photothermal conversion
KW - photothermal therapy
UR - http://www.scopus.com/inward/record.url?scp=85175270546&partnerID=8YFLogxK
U2 - 10.1021/acsnano.3c05244
DO - 10.1021/acsnano.3c05244
M3 - 文章
C2 - 37831502
AN - SCOPUS:85175270546
SN - 1936-0851
VL - 17
SP - 20024
EP - 20033
JO - ACS Nano
JF - ACS Nano
IS - 20
ER -