TY - JOUR
T1 - Stochastic fluctuation induced the competition between extinction and recurrence in a model of tumor growth
AU - Li, Dongxi
AU - Xu, Wei
AU - Sun, Chunyan
AU - Wang, Liang
PY - 2012/4/30
Y1 - 2012/4/30
N2 - We investigate the phenomenon that stochastic fluctuation induced the competition between tumor extinction and recurrence in the model of tumor growth derived from the catalytic Michaelis-Menten reaction. We analyze the probability transitions between the extinction state and the state of the stable tumor by the Mean First Extinction Time (MFET) and Mean First Return Time (MFRT). It is found that the positional fluctuations hinder the transition, but the environmental fluctuations, to a certain level, facilitate the tumor extinction. The observed behavior could be used as prior information for the treatment of cancer.
AB - We investigate the phenomenon that stochastic fluctuation induced the competition between tumor extinction and recurrence in the model of tumor growth derived from the catalytic Michaelis-Menten reaction. We analyze the probability transitions between the extinction state and the state of the stable tumor by the Mean First Extinction Time (MFET) and Mean First Return Time (MFRT). It is found that the positional fluctuations hinder the transition, but the environmental fluctuations, to a certain level, facilitate the tumor extinction. The observed behavior could be used as prior information for the treatment of cancer.
KW - Model of tumor growth
KW - Stochastic fluctuation
KW - Tumor extinction
KW - Tumor recurrence
UR - http://www.scopus.com/inward/record.url?scp=84860363228&partnerID=8YFLogxK
U2 - 10.1016/j.physleta.2012.04.006
DO - 10.1016/j.physleta.2012.04.006
M3 - 文章
AN - SCOPUS:84860363228
SN - 0375-9601
VL - 376
SP - 1771
EP - 1776
JO - Physics Letters, Section A: General, Atomic and Solid State Physics
JF - Physics Letters, Section A: General, Atomic and Solid State Physics
IS - 22
ER -
