TY - JOUR
T1 - Response of osteoblasts to the stimulus of fluid flow
AU - Huang, Ling Wei
AU - Ren, Li
AU - Yang, Peng Fei
AU - Shang, Peng
N1 - Publisher Copyright:
© 2015 Begell House, Inc.
PY - 2015
Y1 - 2015
N2 - Bone is an important porous tissue that supports the body, maintains calcium and phosphate homeostasis, protects vital organs, and houses bone marrow. The interaction between hydrostatic pressure and fluid phase, solid phase, cells, and vascular in bone makes bone inevitably bear baseline levels of fluid flow. Fluid flow plays an important role in regulating the proliferation, differentiation, distribution, and apoptosis of osteoblasts in bone. The effect of fluid flow on osteoblasts is dependent on time, velocity, and type. Some response of osteoblasts to fluid flow is closely related to the soluble factors secreted by the osteoblasts themselves or other types of bone cells. When the response is disordered, related bone diseases such as osteoporosis, osteoarthritis, and abnormal osteogenesis probably happen. In this article we review the current progress in the study of the response of osteoblasts to the direct and indirect stimulus of fluid flow and their roles in osteogenesis and related bone diseases.
AB - Bone is an important porous tissue that supports the body, maintains calcium and phosphate homeostasis, protects vital organs, and houses bone marrow. The interaction between hydrostatic pressure and fluid phase, solid phase, cells, and vascular in bone makes bone inevitably bear baseline levels of fluid flow. Fluid flow plays an important role in regulating the proliferation, differentiation, distribution, and apoptosis of osteoblasts in bone. The effect of fluid flow on osteoblasts is dependent on time, velocity, and type. Some response of osteoblasts to fluid flow is closely related to the soluble factors secreted by the osteoblasts themselves or other types of bone cells. When the response is disordered, related bone diseases such as osteoporosis, osteoarthritis, and abnormal osteogenesis probably happen. In this article we review the current progress in the study of the response of osteoblasts to the direct and indirect stimulus of fluid flow and their roles in osteogenesis and related bone diseases.
KW - Biomechanical response
KW - Bone
KW - Fluid flow
KW - Osteoblast
KW - Stimulus
UR - http://www.scopus.com/inward/record.url?scp=84932647272&partnerID=8YFLogxK
U2 - 10.1615/CritRevEukaryotGeneExpr.2015013564
DO - 10.1615/CritRevEukaryotGeneExpr.2015013564
M3 - 文章
C2 - 26080609
AN - SCOPUS:84932647272
SN - 1045-4403
VL - 25
SP - 153
EP - 162
JO - Critical Reviews in Eukaryotic Gene Expression
JF - Critical Reviews in Eukaryotic Gene Expression
IS - 2
ER -