Responds of Bone Cells to Microgravity: Ground-Based Research

Jian Zhang, Jingbao Li, Huiyun Xu, Pengfei Yang, Li Xie, Airong Qian, Yong Zhao, Peng Shang

科研成果: 期刊稿件文章同行评审

10 引用 (Scopus)

摘要

Severe loss of bone occurs due to long-duration spaceflight. Mechanical loading stimulates bone formation, while bone degradation happens under mechanical unloading. Bone remodeling is a dynamic process in which bone formation and bone resorption are tightly coupled. Increased bone resorption and decreased bone formation caused by reduced mechanical loading, generally result in disrupted bone remodeling. Bone remodeling is orchestrated by multiple bone cells including osteoblast, osteocyte, osteoclast and mesenchymal stem cell. It is yet not clear that how these bone cells sense altered gravity, translate physical stimulus into biochemical signals, and then regulate themselves structurally and functionally. In this paper, studies elucidating the bioeffects of microgravity on bone cells (osteoblast, osteocyte, osteoclast, mesenchymal stem cell) using various platforms including spaceflight and ground-based simulated microgravity were summarized. Promising gravity-sensitive signaling pathways and protein molecules were proposed.

源语言英语
页(从-至)455-464
页数10
期刊Microgravity Science and Technology
27
6
DOI
出版状态已出版 - 1 11月 2015

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