Reference genome of wild goat (capra aegagrus) and sequencing of goat breeds provide insight into genic basis of goat domestication

Yang Dong, Xiaolei Zhang, Min Xie, Babak Arefnezhad, Zongji Wang, Wenliang Wang, Shaohong Feng, Guodong Huang, Rui Guan, Wenjing Shen, Rowan Bunch, Russell McCulloch, Qiye Li, Bo Li, Guojie Zhang, Xun Xu, James W. Kijas, Ghasem Hosseini Salekdeh, Wen Wang, Yu Jiang

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89 引用 (Scopus)

摘要

Domestic goats (Capra hircus) have been selected to play an essential role in agricultural production systems, since being domesticated from their wild progenitor, bezoar (Capra aegagrus). A detailed understanding of the genetic consequences imparted by the domestication process remains a key goal of evolutionary genomics. Results: We constructed the reference genome of bezoar and sequenced representative breeds of domestic goats to search for genomic changes that likely have accompanied goat domestication and breed formation. Thirteen copy number variation genes associated with coat color were identified in domestic goats, among which ASIP gene duplication contributes to the generation of light coat-color phenotype in domestic goats. Analysis of rapidly evolving genes identified genic changes underlying behavior-related traits, immune response and production-related traits. Conclusion: Based on the comparison studies of copy number variation genes and rapidly evolving genes between wild and domestic goat, our findings and methodology shed light on the genetic mechanism of animal domestication and will facilitate future goat breeding.

源语言英语
文章编号431
期刊BMC Genomics
16
1
DOI
出版状态已出版 - 5 6月 2015
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