TY - JOUR
T1 - Precise Design of TiO2@CoOx Heterostructure via Atomic Layer Deposition for Synergistic Sono-Chemodynamic Oncotherapy
AU - Liu, Wen
AU - Shao, Runrun
AU - Guo, Lingyun
AU - Man, Jianliang
AU - Zhang, Chengwu
AU - Li, Lihong
AU - Wang, Haojiang
AU - Wang, Bin
AU - Guo, Lixia
AU - Ma, Sufang
AU - Zhang, Bin
AU - Diao, Haipeng
AU - Qin, Yong
AU - Yan, Lili
N1 - Publisher Copyright:
© 2024 The Authors. Advanced Science published by Wiley-VCH GmbH.
PY - 2024/4/10
Y1 - 2024/4/10
N2 - Sonodynamic therapy (SDT), a tumor treatment modality with high tissue penetration and low side effects, is able to selectively kill tumor cells by producing cytotoxic reactive oxygen species (ROS) with ultrasound-triggered sonosensitizers. N-type inorganic semiconductor TiO2 has low ROS quantum yields under ultrasound irradiation and inadequate anti-tumor activity. Herein, by using atomic layer deposition (ALD) to create a heterojunction between porous TiO2 and CoOx, the sonodynamic therapy efficiency of TiO2 can be improved. Compared to conventional techniques, the high controllability of ALD allows for the delicate loading of CoOx nanoparticles into TiO2 pores, resulting in the precise tuning of the interfaces and energy band structures and ultimately optimal SDT properties. In addition, CoOx exhibits a cascade of H2O2→O2→·O2− in response to the tumor microenvironment, which not only mitigates hypoxia during the SDT process, but also contributes to the effect of chemodynamic therapy (CDT). Correspondingly, the synergistic CDT/SDT treatment is successful in inhibiting tumor growth. Thus, ALD provides new avenues for catalytic tumor therapy and other pharmaceutical applications.
AB - Sonodynamic therapy (SDT), a tumor treatment modality with high tissue penetration and low side effects, is able to selectively kill tumor cells by producing cytotoxic reactive oxygen species (ROS) with ultrasound-triggered sonosensitizers. N-type inorganic semiconductor TiO2 has low ROS quantum yields under ultrasound irradiation and inadequate anti-tumor activity. Herein, by using atomic layer deposition (ALD) to create a heterojunction between porous TiO2 and CoOx, the sonodynamic therapy efficiency of TiO2 can be improved. Compared to conventional techniques, the high controllability of ALD allows for the delicate loading of CoOx nanoparticles into TiO2 pores, resulting in the precise tuning of the interfaces and energy band structures and ultimately optimal SDT properties. In addition, CoOx exhibits a cascade of H2O2→O2→·O2− in response to the tumor microenvironment, which not only mitigates hypoxia during the SDT process, but also contributes to the effect of chemodynamic therapy (CDT). Correspondingly, the synergistic CDT/SDT treatment is successful in inhibiting tumor growth. Thus, ALD provides new avenues for catalytic tumor therapy and other pharmaceutical applications.
KW - atomic layer deposition
KW - carrier separation efficiency improvement
KW - energy band structure adaptation
KW - heterostructure
KW - synergistic sono-chemodynamic oncotherapy
UR - http://www.scopus.com/inward/record.url?scp=85184249077&partnerID=8YFLogxK
U2 - 10.1002/advs.202304046
DO - 10.1002/advs.202304046
M3 - 文章
C2 - 38311581
AN - SCOPUS:85184249077
SN - 2198-3844
VL - 11
JO - Advanced Science
JF - Advanced Science
IS - 14
M1 - 2304046
ER -