Individualized ROI optimization via maximization of group-wise consistency of structural and functional profiles

Kaiming Li, Lei Guo, Carlos Faraco, Dajiang Zhu, Fan Deng, Tuo Zhang, Xi Jiang, Degang Zhang, Hanbo Chen, Xintao Hu, Steve Miller, Tianming Liu

科研成果: 书/报告/会议事项章节会议稿件同行评审

30 引用 (Scopus)

摘要

Functional segregation and integration are fundamental characteristics of the human brain. Studying the connectivity among segregated regions and the dynamics of integrated brain networks has drawn increasing interest. A very controversial, yet fundamental issue in these studies is how to determine the best functional brain regions or ROIs (regions of interests) for individuals. Essentially, the computed connectivity patterns and dynamics of brain networks are very sensitive to the locations, sizes, and shapes of the ROIs. This paper presents a novel methodology to optimize the locations of an individual's ROIs in the working memory system. Our strategy is to formulate the individual ROI optimization as a group variance minimization problem, in which group-wise functional and structural connectivity patterns, and anatomic profiles are defined as optimization constraints. The optimization problem is solved via the simulated annealing approach. Our experimental results show that the optimized ROIs have significantly improved consistency in structural and functional profiles across subjects, and have more reasonable localizations and more consistent morphological and anatomic profiles.

源语言英语
主期刊名Advances in Neural Information Processing Systems 23
主期刊副标题24th Annual Conference on Neural Information Processing Systems 2010, NIPS 2010
出版商Neural Information Processing Systems
ISBN(印刷版)9781617823800
出版状态已出版 - 2010
活动24th Annual Conference on Neural Information Processing Systems 2010, NIPS 2010 - Vancouver, BC, 加拿大
期限: 6 12月 20109 12月 2010

出版系列

姓名Advances in Neural Information Processing Systems 23: 24th Annual Conference on Neural Information Processing Systems 2010, NIPS 2010

会议

会议24th Annual Conference on Neural Information Processing Systems 2010, NIPS 2010
国家/地区加拿大
Vancouver, BC
时期6/12/109/12/10

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