Fast response two-photon fluorogenic probe based on Schiff base derivatives for monitoring nitric oxide levels in living cells and zebrafish

Chenchen Xu, Chenqi Xin, Changmin Yu, Meirong Wu, Jiajia Xu, Wenjing Qin, Yang Ding, Xuchun Wang, Lin Li, Wei Huang

科研成果: 期刊稿件文章同行评审

20 引用 (Scopus)

摘要

Numerous excellent fluorogenic probes for NO detection based on NO-mediated reactions have been developed. However, some of them still suffer from limitations such as low selectivity, slow response, and a short excitation wavelength (<500 nm). Herein, a novel two-photon fluorogenic probe (XNO1) based on a Schiff base derivative has been reported for the first time. This new mechanism with a Schiff base structure as the specific response moiety towards NO endows the probe with fast responsibility, high selectivity and pH-independent properties. Furthermore, XNO1 has been demonstrated to be lysosome-targeted and to successfully monitor exogenous/endogenous NO in living cells and zebrafishes with one- and two-photon fluorescence imaging.

源语言英语
页(从-至)13491-13494
页数4
期刊Chemical Communications
54
96
DOI
出版状态已出版 - 2018

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