Facile Synthesis of Polysubstituted Indolizines via One-Pot Reaction of 1-Acetylaryl 2-Formylpyrroles and Enals

Minghua Gong, Jingcheng Guo, Pengrui Jiang, Ye Zhang, Zhenqian Fu, Wei Huang

科研成果: 期刊稿件文章同行评审

10 引用 (Scopus)

摘要

An efficient method for the synthesis of polysubstituted indolizines has been developed based on formal [4+2] annulation of 1-acetylaryl 2-formylpyrroles with enals, followed by oxidative aromatization. Pyridine-type six-membered rings were constructed in this transformation. This transition metal-free reaction features mild reaction conditions, a broad substrate scope, and excellent functional group tolerance. Notably, the formyl group is well tolerated under reaction conditions.

源语言英语
页(从-至)352-355
页数4
期刊Chemistry - An Asian Journal
15
3
DOI
出版状态已出版 - 3 2月 2020

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